The P2X7 purinergic receptor in intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30611
Abstract: Mechanisms involved in the development of intervertebral disc (IVD) degeneration are only partially known, thus making the implementation of effective therapies very difficult. In this study, we investigated P2X7 purinergic receptor (P2X7R), NLRP3 inflammasome, and… read more here.
Keywords: p2x7r nlrp3; p2x7r; intervertebral disc; purinergic receptor ... See more keywords
Inhibition of P2X7 Purinergic Receptor Ameliorates Cardiac Fibrosis by Suppressing NLRP3/IL-1β Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/7956274
Abstract: P2X7 purinergic receptor (P2X7R) has been implicated in several cardiovascular diseases. However, whether it regulates cardiac fibrosis remains elusive. Herein, its involvement in the development of cardiac fibrosis was examined using a transverse aortic constriction… read more here.
Keywords: fibrosis; cardiac fibrosis; purinergic receptor; p2x7 purinergic ... See more keywords
P2X7 purinergic receptor: A potential target in heart diseases (Review).
Sign Up to like & getrecommendations! Published in 2023 at "Molecular medicine reports"
DOI: 10.3892/mmr.2023.12961
Abstract: The P2X7 purinergic receptor (P2X7R) is a non‑selective cation channel activated by high levels of adenosine triphosphate that are commonly present in serious conditions. Activation of this purinergic receptor is closely related to the development… read more here.
Keywords: purinergic receptor; p2x7 purinergic; heart diseases; development ... See more keywords