P2X7 receptor‐mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Pain"
DOI: 10.1002/ejp.1951
Abstract: P2X7 receptor antagonists have potential for treating various central nervous system (CNS) diseases, including neuropathic pain, although none have been approved for clinical use. Reasons may include insufficient understanding of P2X7 receptor signalling in pain,… read more here.
Keywords: p2x7 receptor; receptor mediated; release microglial; mediated release ... See more keywords
N-terminal tagging of human P2X7 receptor disturbs calcium influx and dye uptake
Sign Up to like & getrecommendations! Published in 2017 at "Purinergic Signalling"
DOI: 10.1007/s11302-017-9598-8
Abstract: The P2X7 receptor is a frequently studied member of the purinergic receptor family signalling via channel opening and membrane pore formation. Fluorescent imaging is an important molecular method for studying cellular receptor expression and localization.… read more here.
Keywords: human p2x7; channel opening; receptor; p2x7 receptor ... See more keywords
Administration of an antagonist of P2X7 receptor to EAE rats prevents a decrease of expression of claudin-5 in cerebral capillaries
Sign Up to like & getrecommendations! Published in 2018 at "Purinergic Signalling"
DOI: 10.1007/s11302-018-9620-9
Abstract: Purinergic P2X receptors, when activated under pathological conditions, participate in induction of the inflammatory response and/or cell death. Both neuroinflammation and neurodegeneration represent hallmarks of multiple sclerosis (MS), an autoimmune disease of the central nervous… read more here.
Keywords: administration; expression claudin; eae; p2x7 receptor ... See more keywords
P2X7: a receptor with a split personality that raises new hopes for anti-cancer therapy
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic Signalling"
DOI: 10.1007/s11302-021-09783-w
Abstract: Alba Clara Sarti is currently a post-doctoral researcher at the Department of Medical Sciences and a trainee in the Postgraduate School in Clinical Pathology and Clinical Biochemistry at the University of Ferrara. She received a… read more here.
Keywords: split personality; receptor split; personality raises; p2x7 receptor ... See more keywords
Cannabinoids Induce Cell Death and Promote P2X7 Receptor Signaling in Retinal Glial Progenitors in Culture
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-1537-y
Abstract: Development of progenitors in the embryonic retina is modulated by signaling molecules, and cannabinoid receptors are highly expressed in the early developing retina. Here, we investigated whether the CB1/CB2 receptor agonist WIN 5212-2 (WIN) modulated… read more here.
Keywords: receptor; p2x7 receptor; cell; progenitors culture ... See more keywords
Enteric glial cells immunoreactive for P2X7 receptor are affected in the ileum following ischemia and reperfusion.
Sign Up to like & getrecommendations! Published in 2019 at "Acta histochemica"
DOI: 10.1016/j.acthis.2019.06.001
Abstract: The aim of this study was to analyze the effect of ischemia and reperfusion injury (IS) on enteric glial cells (EGCs) and neurons immunoreactive for the P2X7 receptor. Intestinal ischemia was induced by obstructing blood… read more here.
Keywords: immunoreactive p2x7; glial cells; reperfusion; receptor ... See more keywords
P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114199
Abstract: To investigate the role of P2X7 receptor to preserve retinal ganglion cells (RGCs) structure and function in a genetic mouse model (DBA/2J mouse) of age-related glaucomatous neurodegeneration. Chronic treatment with P2X7 receptor antagonist eye drops… read more here.
Keywords: glaucomatous mice; retinal ganglion; ganglion cells; receptor ... See more keywords
P2X7 receptor and the NLRP3 inflammasome: partners in crime.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114385
Abstract: Adenosine triphosphate (ATP) is a molecule that on one hand plays a central role in cellular energetics and which on the other is a ubiquitous signaling molecule when released into the extracellular media. Extracellular ATP… read more here.
Keywords: inflammasome partners; receptor; p2x7 receptor; receptor nlrp3 ... See more keywords
Targeting P2X7 receptors as a means for treating retinal disease.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.03.029
Abstract: Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. The purine ATP is known to regulate a range of cellular functions in the retina via its action on… read more here.
Keywords: targeting p2x7; disease; p2x7 receptors; receptors means ... See more keywords
Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.12.006
Abstract: ABSTRACT The purinergic receptor P2X ligand‐gated ion channel 7 (P2X7 receptor) is a promising imaging target to detect neuroinflammation. Herein, we report development of a potent iodinated radiotracer for P2X7 receptor, [123I]TZ6019. The radiosynthesis of… read more here.
Keywords: receptor; p2x7 receptor; 123i tz6019; neuroinflammation ... See more keywords
Evaluation of P2X7 Receptor Expression in the Kidney at the Early Phase of Experimental Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.231
Abstract: Introduction Diabetes mellitus is the largest epidemic disease of the 21st century and the International Diabetes Federation estimated that around 415 million people were diagnosed as diabetic by the year 2015; the projections for 2035… read more here.
Keywords: phase; p2x7 receptor; diabetes mellitus; evaluation p2x7 ... See more keywords