The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression
Sign Up to like & getrecommendations! Published in 2017 at "Purinergic Signalling"
DOI: 10.1007/s11302-017-9593-0
Abstract: Seven P2X ion channel nucleotide receptor subtypes have been cloned and characterised. P2X7 receptors (P2X7R) are unusual in that there are extra amino acids in the intracellular C terminus. Low concentrations of ATP open cation… read more here.
Keywords: p2x7 receptors; tumour progression; potential p2x7; inflammation ... See more keywords
Involvement of P2X7 receptors in chronic pain disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic signalling"
DOI: 10.1007/s11302-021-09796-5
Abstract: Chronic pain is caused by cellular damage with an obligatory inflammatory component. In response to noxious stimuli, high levels of ATP leave according to their concentration gradient, the intracellular space through discontinuities generated in the… read more here.
Keywords: pain; p2x7 receptors; involvement p2x7; pain disorders ... See more keywords
P2X7 receptors in the central nervous system.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114472
Abstract: For the past three decades, our laboratory has conducted pioneering research to elucidate the complexity of purinergic signaling in the CNS, alone and in collaboration with other groups, inspired by the ground-breaking efforts of Geoffrey… read more here.
Keywords: nervous system; receptors central; central nervous; p2x7 receptors ... See more keywords
Targeting P2X7 receptors as a means for treating retinal disease.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.03.029
Abstract: Age-related macular degeneration and glaucoma are the commonest causes of irreversible vision loss in industrialized countries. The purine ATP is known to regulate a range of cellular functions in the retina via its action on… read more here.
Keywords: targeting p2x7; disease; p2x7 receptors; receptors means ... See more keywords
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00965-3
Abstract: Scientists and health professionals are exhaustively trying to contain the coronavirus disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible drugs to prevent viral infection/replication, and health cares to minimize individual exposure. Although neurological… read more here.
Keywords: p2x7; hyperactivation p2x7; infection; p2x7 receptors ... See more keywords
Flow cytometry identifies an early stage of platelet apoptosis produced by agonists of the P2X1 and P2X7 receptors
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2021.1981844
Abstract: Abstract Platelets express P2X1 receptors and our data also show the expression of P2X7 receptors. We studied the role of both receptors in platelet apoptosis by incubation of PRP with P2X agonists, then centrifuged to… read more here.
Keywords: platelet apoptosis; p2x7 receptors; apoptosis; early stage ... See more keywords
Ionotropic P2X4 and P2X7 receptors in the regulation of ion transport across rat colon
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15928
Abstract: ATP plays an important role as an extracellular messenger acting via different types of purinoceptors. Whereas most of the actions of ATP at intestinal epithelia are thought to be mediated by metabotropic P2Y receptors, the… read more here.
Keywords: p2x7; transport across; p2x4 p2x7; p2x7 receptors ... See more keywords
ATP Signaling Controlling Dyskinesia Through P2X7 Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2020.00111
Abstract: Dopamine replacement therapy with L-3,4-dihydroxyphenylalanine (L-DOPA) is the only temporary therapy for Parkinson’s disease (PD), but it triggers dyskinesia over time. Since dyskinesia is associated with increased neuronal firing that bolsters purinergic signaling, we now… read more here.
Keywords: controlling dyskinesia; p2x7; signaling controlling; p2x7 receptors ... See more keywords
Interaction between Calcium Chelators and the Activity of P2X7 Receptors in Mouse Motor Synapses
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21062034
Abstract: The ability of P2X7 receptors to potentiate rhythmically evoked acetylcholine (ACh) release through Ca2+ entry via P2X7 receptors and via L-type voltage-dependent Ca2+ channels (VDCCs) was compared by loading Ca2+ chelators into motor nerve terminals.… read more here.
Keywords: quantal content; p2x7 receptors; motor; ca2 ... See more keywords