The P2X7 purinergic receptor in intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30611
Abstract: Mechanisms involved in the development of intervertebral disc (IVD) degeneration are only partially known, thus making the implementation of effective therapies very difficult. In this study, we investigated P2X7 purinergic receptor (P2X7R), NLRP3 inflammasome, and… read more here.
Keywords: p2x7r nlrp3; p2x7r; intervertebral disc; purinergic receptor ... See more keywords
P2X7R: independent modulation of aquaporin 5 expression in CdCl2-injured alveolar epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Histochemistry and Cell Biology"
DOI: 10.1007/s00418-018-1637-1
Abstract: The expression of aquaporin 5 in alveolar epithelial type I cells under conditions of cadmium-induced injury has not yet been discovered. We investigated the effect of the P2X7R agonist BzATP under this condition, since P2X7R… read more here.
Keywords: epithelial type; type cells; p2x7r; expression ... See more keywords
Increased expression of P2X7 receptor in peripheral blood mononuclear cells correlates with clinical severity and serum levels of Th17-related cytokines in patients with myasthenia gravis
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2017.04.012
Abstract: OBJECTIVES P2X7R is a well-documented activator of innate and adaptive immune responses. We aimed to measure the expression levels of P2X7R in peripheral blood mononuclear cells (PBMCs) from patients with myasthenia gravis (MG) and to… read more here.
Keywords: serum; p2x7r; peripheral blood; expression ... See more keywords
High expression of P2X7R is an independent postoperative indicator of poor prognosis in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Human pathology"
DOI: 10.1016/j.humpath.2017.03.019
Abstract: The purinergic P2X7 receptor (P2X7R) is a master regulator of inflammation and inflammation-related diseases. Recently, P2X7R has been reportedly involved in carcinogenesis and tumor progression. In this study, we investigated the expression pattern and prognostic… read more here.
Keywords: indicator; colorectal cancer; p2x7r; expression ... See more keywords
Rutin mitigates hepatic fibrogenesis and inflammation through targeting TLR4 and P2X7 receptor signaling pathway in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Functional Foods"
DOI: 10.1016/j.jff.2019.103700
Abstract: Abstract Rutin is a flavonol glycoside widely existing in plants, used as food antioxidant and nutritional enhancer. Rutin has vitamin P-like effect and anti-inflammatory effect. This study aims to investigate the effects and potential mechanisms… read more here.
Keywords: fibrosis; vivo; signaling pathway; p2x7r ... See more keywords
PET Imaging of P2X7 Receptor (P2X7R) for Neuroinflammation with Improved Radiosynthesis of Tracer [18F]4A in Mice and Non-human Primates.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00506
Abstract: The P2X7 receptor (P2X7R) is a key neuroinflammation target in a variety of neurodegenerative diseases. Improved radiosynthesis was developed according to the previously reported P2X7R antagonist GSK1482160. Biodistribution, radiometabolite, and dynamic positron emission tomography/computed tomography-magnetic… read more here.
Keywords: p2x7 receptor; receptor p2x7r; neuroinflammation; p2x7r ... See more keywords
Characterization of the Novel P2X7 Receptor Radioligand [3H]JNJ-64413739 in Human Brain Tissue
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00561
Abstract: Radioligands targeting microglia cells have been developed to identify and determine neuroinflammation in the living brain. One recently discovered ligand is JNJ-64413739 that binds selectively to the purinergic receptor P2X7R. The expression of P2X7R is… read more here.
Keywords: jnj; jnj 64413739; human brain; p2x7r ... See more keywords
Astrocyte adaptation in Alzheimer’s disease: a focus on astrocytic P2X7R
Sign Up to like & getrecommendations! Published in 2022 at "Essays in Biochemistry"
DOI: 10.1042/ebc20220079
Abstract: Abstract Astrocytes are key homeostatic and defensive cells of the central nervous system (CNS). They undertake numerous functions during development and in adulthood to support and protect the brain through finely regulated communication with other… read more here.
Keywords: disease; alzheimer disease; astrocyte adaptation; astrocytic p2x7r ... See more keywords
Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15785
Abstract: BACKGROUND AND PURPOSE Refractory status epilepticus is a clinical emergency associated with high mortality and morbidity. Increasing evidence suggests neuroinflammation contributes to the development of drug-refractoriness during status epilepticus. The aim of the present study… read more here.
Keywords: gated p2x7; atp gated; p2x7r; status ... See more keywords
Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures
Sign Up to like & getrecommendations! Published in 2017 at "BioMed Research International"
DOI: 10.1155/2017/9547902
Abstract: Objectives. Clinical and experimental evidence has clarified that the inflammatory processes within the brain play a pivotal role in the pathophysiology of seizures and epilepsy. Inflammasomes and P2X7 purinergic receptor (P2X7R) are important mediators during… read more here.
Keywords: p2x7r gene; gene polymorphisms; p2x7r; partial seizures ... See more keywords
Antidepressant-like effect induced by P2X7 receptor blockade in FSL rats is associated with BDNF signalling activation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Psychopharmacology"
DOI: 10.1177/0269881119872173
Abstract: Background: P2X7 receptors (P2X7R) are ligand-gated ion channels activated by adenosine 5’-triphosphate (ATP), which are involved in processes that are dysfunctional in stress response and depression, such as neurotransmitter release, and neuroimmune response. Genetic and… read more here.
Keywords: bdnf signalling; blockade; like effect; effect ... See more keywords