The P2X7 purinergic receptor in intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30611
Abstract: Mechanisms involved in the development of intervertebral disc (IVD) degeneration are only partially known, thus making the implementation of effective therapies very difficult. In this study, we investigated P2X7 purinergic receptor (P2X7R), NLRP3 inflammasome, and… read more here.
Keywords: p2x7r nlrp3; p2x7r; intervertebral disc; purinergic receptor ... See more keywords
Vitexin Alleviates Kainic Acid-Induced Seizure Through Inhibiting P2X7R/NLRP3 Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Inflammation"
DOI: 10.1007/s10753-025-02324-2
Abstract: Epilepsy, a prevalent chronic brain disorder, remains inadequately controlled by current antiepileptic drugs. Neuroinflammation is considered a crucial component in the process of epileptogenesis. Vitexin (VT), primarily derived from medicinal plants, is a flavonoid monomer… read more here.
Keywords: inhibiting p2x7r; kainic acid; p2x7r nlrp3; induced seizure ... See more keywords
The Role of the Hippocampal P2X7R/NLRP3 Signaling Pathway in Depression-Like Behavior Induced by the Interaction Between Chronic Stress and Time in a Rat Model of Stroke.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of integrative neuroscience"
DOI: 10.31083/jin40005
Abstract: BACKGROUND Depression frequently manifests as a secondary affective disorder in individuals who have experienced a stroke. In laboratory rats subjected to stroke, prolonged exposure to chronic stress effectively replicates the physiological impairment and adverse environmental… read more here.
Keywords: time; stress; depression; p2x7r nlrp3 ... See more keywords
The P2X7R-NLRP3 and AIM2 Inflammasome Platforms Mark the Complexity/Severity of Viral or Metabolic Liver Damage
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137447
Abstract: P2X7R-NLRP3 and AIM2 inflammasomes activate caspase-1 and the release of cytokines involved in viral-related liver disease. Little is known about their role in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steato-hepatitis (NASH). We characterized the… read more here.
Keywords: p2x7r nlrp3; expression; hcv; aim2 inflammasome ... See more keywords