Diverse signalling of the platelet P2Y1 receptor leads to a dichotomy in platelet function
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.014
Abstract: Abstract Platelet P2Y1 receptor signalling via RhoGTPases is necessary for platelet‐dependent leukocyte recruitment, where no platelet aggregation is observed. We investigated signalling cascades involved in distinct P2Y1‐dependent platelet activities in vitro, using specific inhibitors for… read more here.
Keywords: aggregation; p2y1 receptor; p2y1; platelet p2y1 ... See more keywords
Demystifying P2Y1 Receptor Ligand Recognition through Docking and Molecular Dynamics Analyses.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00528
Abstract: We performed a molecular modeling analysis of 100 nucleotide-like bisphosphates and 46 non-nucleotide arylurea derivatives previously reported as P2Y1R binders using the recently solved hP2Y1R structures. We initially docked the compounds at the X-ray structures… read more here.
Keywords: receptor ligand; molecular dynamics; p2y1 receptor; demystifying p2y1 ... See more keywords
Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent
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DOI: 10.1038/s41598-019-55194-8
Abstract: Purinergic receptor is a potential drug target for neuropathic pain, Alzheimer disease, and prostate cancer. Focusing on the structure-based ligand discovery, docking analysis on the crystal structure of P2Y1 receptor (P2Y1R) with 923 derivatives of… read more here.
Keywords: receptor; p2y1 receptor; prostate cancer;
Extracellular Adenosine Diphosphate Stimulates CXCL10-Mediated Mast Cell Infiltration Through P2Y1 Receptor to Aggravate Airway Inflammation in Asthmatic Mice
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.621963
Abstract: Asthma is an inflammatory disease associated with variable airflow obstruction and airway inflammation. This study aimed to explore the role and mechanism of extracellular adenosine diphosphate (ADP) in the occurrence of airway inflammation in asthma.… read more here.
Keywords: p2y1 receptor; adp; inflammation; airway inflammation ... See more keywords