Role of P2Y12 Receptor in Thrombosis.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2016_123
Abstract: P2Y12 receptor is a 342 amino acid Gi-coupled receptor predominantly expressed on platelets. P2Y12 receptor is physiologically activated by ADP and inhibits adenyl cyclase (AC) to decrease cyclic AMP (cAMP) level, resulting in platelet aggregation.… read more here.
Keywords: antiplatelet; thrombosis; role; receptor ... See more keywords
Body weight, CYP2C19, and P2Y12 receptor polymorphisms relate to clopidogrel resistance in a cohort of Chinese ischemic stroke patients with aspirin intolerance
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-020-02946-5
Abstract: Dual antiplatelet therapy (DAT) with clopidogrel and aspirin is not suitable for clopidogrel resistance (CR) patients with aspirin intolerance. To investigate the prevalence of CR in patients with aspirin intolerance after ischemic stroke (IS) and… read more here.
Keywords: clopidogrel; aspirin intolerance; patients aspirin; p2y12 receptor ... See more keywords
Caspase-1 inhibition by VX-765 administered at reperfusion in P2Y12 receptor antagonist-treated rats provides long-term reduction in myocardial infarct size and preservation of ventricular function
Sign Up to like & getrecommendations! Published in 2018 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-018-0692-z
Abstract: Patients with acute myocardial infarction receive a P2Y12 receptor antagonist prior to reperfusion, a treatment that has reduced, but not eliminated, mortality, or heart failure. We tested whether the caspase-1 inhibitor VX-765 given at reperfusion… read more here.
Keywords: reperfusion; infarction; p2y12 receptor; receptor antagonist ... See more keywords
The role of P2Y12 receptor inhibition in ischemic stroke on microglia, platelets and vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Thrombolysis"
DOI: 10.1007/s11239-020-02098-4
Abstract: P2Y12 receptors on platelets have long been the main target of antiplatelet drugs. However, a growing number of studies have revealed that P2Y12 receptor activation on microglia and vascular smooth muscle cells (VSMCs) also aggravates… read more here.
Keywords: ischemic stroke; p2y12; vascular smooth; muscle cells ... See more keywords
Study of the Involvement of the P2Y12 Receptor in Chronic Itching in Type 2 Diabetes Mellitus.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02676-4
Abstract: Itching is a common clinical symptom in diabetic patients. This research is to carry out experiments on the pathological changes in the P2Y12 receptor in type 2 diabetes mellitus complicated with chronic itching. Changes in… read more here.
Keywords: type diabetes; chronic itching; diabetes mellitus; p2y12 receptor ... See more keywords
P2Y12 receptor antagonists and AR receptor agonists regulates Protein Disulfide Isomerase secretion from platelets and endothelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.03.143
Abstract: Secretion of PDI from platelets and endothelial cells is an important step of all thrombotic events. In the absence of extracellular PDI thrombus formation and fibrin generation may be impaired. Thrombin-mediated PDI secretion is regulated… read more here.
Keywords: secretion; platelets endothelial; endothelial cells; receptor antagonists ... See more keywords
Antithrombotic P2Y12 receptor antagonists: recent developments in drug discovery.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2018.09.021
Abstract: The P2Y12 receptor is one of eight known P2Y receptor subtypes, and belongs to the G-protein-coupled receptor (GPCR) family. The P2Y12 receptor is highly expressed on blood platelets and in the brain. Potent, selective, peripherally… read more here.
Keywords: receptor; drug discovery; p2y12 receptor; receptor antagonists ... See more keywords
Reply: Delayed onset of novel P2Y12 receptor antagonists action post fibrinolysis.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2017.02.034
Abstract: Univ Fed Sao Paulo, Escola Paulista Med, Rua Napoleao Barros 715, BR-04024002 Sao Paulo, Brazil read more here.
Keywords: novel p2y12; delayed onset; onset novel; receptor antagonists ... See more keywords
Clash of Oral P2Y12 Receptor Inhibitors in Acute Coronary Syndromes.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.12.004
Abstract: SEE PAGE 371 P 2Y12 receptors on platelet membrane are key modulators of platelet aggregation and thrombosis in acute coronary syndromes (2). Oral P2Y12 receptor inhibitors (clopidogrel, ticagrelor, and prasugrel) combined with aspirin (dual antiplatelet… read more here.
Keywords: receptor inhibitors; oral p2y12; acute coronary; coronary syndromes ... See more keywords
Selection of P2Y12 Inhibitor in Percutaneous Coronary Intervention and/or Acute Coronary Syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Progress in cardiovascular diseases"
DOI: 10.1016/j.pcad.2018.01.003
Abstract: The P2Y12 receptor plays a critical role in the amplification of platelet aggregation in response to various agonists and stable thrombus generation at the site of vascular injury leading to deleterious ischemic complications. Therefore, treatment… read more here.
Keywords: risk; p2y12; acute coronary; percutaneous coronary ... See more keywords
Antagonizing P2Y12 Receptor Inhibitors: Current and Future Options.
Sign Up to like & getrecommendations! Published in 2019 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0039-1693738
Abstract: There are clinical scenarios where the balance between the risk of ischemic and bleeding events leads to the clinical decision to reverse the antiplatelet effect of P2Y12 receptor inhibitors. These scenarios comprise emergency situations such… read more here.
Keywords: administration; antagonizing p2y12; receptor inhibitors; effect ... See more keywords