Microglial P2Y14 receptor contributes to central sensitization following repeated inflammatory dural stimulation
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2021.09.013
Abstract: BACKGROUND Recent studies have indicated that P2Y receptors in spinal microglia play a role in the development of neuropathic and inflammatory pain. However, it remains unclear whether P2Y receptors in microglia are involved in the… read more here.
Keywords: migraine; microglial p2y14; stimulation; p2y14 receptor ... See more keywords
The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.104567
Abstract: P2Y purinergic receptors expressed in neurons and satellite glial cells (SGCs) of the trigeminal ganglion (TG) contributes to inflammatory and neuropathic pain. P2Y14 receptor expression is reported in the spinal cord, dorsal root ganglion (DRG),… read more here.
Keywords: p2y14 receptor; receptor; pain; trigeminal ganglion ... See more keywords
Structure-Guided Modification of Heterocyclic Antagonists of the P2Y14 Receptor.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00168
Abstract: The P2Y14 receptor (P2Y14R) mediates inflammatory activity by activating neutrophil motility, but few classes of antagonists are known. We have explored the structure-activity relationship of a 3-(4-phenyl-1 H-1,2,3-triazol-1-yl)-5-(aryl)benzoic acid antagonist scaffold, assisted by docking and… read more here.
Keywords: guided modification; structure guided; phenyl; p2y14 receptor ... See more keywords
Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2Y14 Receptor in Superior Cervical Ganglion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.873090
Abstract: Diabetes mellitus (DM), an emerging chronic epidemic, contributes to mortality and morbidity around the world. Diabetic cardiac autonomic neuropathy (DCAN) is one of the most common complications associated with DM. Previous studies have shown that… read more here.
Keywords: cardiac autonomic; mediated p2y14; superior cervical; diabetic cardiac ... See more keywords