Discovery of N-Substituted Acetamide Derivatives as Promising P2Y14R Antagonists Using Molecular Hybridization Based on Crystallographic Overlay.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c00555
Abstract: P2Y14 receptor (P2Y14R) is activated by uridine 5'-diphosphate-glucose, which is involved in many human inflammatory diseases. Based on the molecular docking analysis of currently reported P2Y14R antagonists and the crystallographic overlap study between the reported… read more here.
Keywords: substituted acetamide; p2y14r; acetamide derivatives; derivatives promising ... See more keywords
1705-P: Adipocyte Specific Ablation of P2Y14R Improves Glucose Metabolism in Mice with Diet-Induced Obesity
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DOI: 10.2337/db20-1705-p
Abstract: Adipose tissue is one of the major tissues in body regulating glucose and energy homeostasis. White adipose tissue (iWAT) serves as primary site of energy storage while brown (BAT) and beige AT play a major… read more here.
Keywords: glucose metabolism; mice; p2y14r; diet ... See more keywords