Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01964
Abstract: High affinity phenyl-piperidine P2Y14R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopentylamino derivatives preserved human P2Y14R affinity (fluorescence binding assay),… read more here.
Keywords: piperidine; high affinity; affinity; bridged piperidine ... See more keywords