Articles with "p2y14r antagonist" as a keyword



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Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y14R Antagonist.

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Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c01964

Abstract: High affinity phenyl-piperidine P2Y14R antagonist 1 (PPTN) was modified with piperidine bridging moieties to probe receptor affinity and hydrophobicity. Various 2-azanorbornane, nortropane, isonortropane, isoquinuclidine, and ring-opened cyclopentylamino derivatives preserved human P2Y14R affinity (fluorescence binding assay),… read more here.

Keywords: piperidine; high affinity; affinity; bridged piperidine ... See more keywords