Mapping the Binding Sites of UDP and Prostaglandin E2 Glyceryl Ester in the Nucleotide Receptor P2Y6
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DOI: 10.1002/cmdc.202100683
Abstract: Cyclooxygenase‐2 catalyzes the biosynthesis of prostaglandins from arachidonic acid and the biosynthesis of prostaglandin glycerol esters (PG‐Gs) from 2‐arachidonoylglycerol. PG‐Gs are mediators of several biological actions such as macrophage activation, hyperalgesia, synaptic plasticity, and intraocular… read more here.
Keywords: ester; receptor p2y6; mapping binding; p2y6 ... See more keywords
miR-185/P2Y6 Axis Inhibits Angiotensin II-Induced Human Aortic Vascular Smooth Muscle Cell Proliferation.
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DOI: 10.1089/dna.2016.3605
Abstract: The abnormal proliferation and apoptosis of human aortic vascular smooth muscle cells (HAVSMCs) play an important role in the pathogenesis of hypertension. Recent study revealed that angiotensin II (Ang II) could elicit HAVSMC dysfunction, to… read more here.
Keywords: mir 185; aortic vascular; vascular smooth; proliferation ... See more keywords
Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy.
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DOI: 10.1172/jci.insight.93456
Abstract: Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs) and visual loss. Although one of the highest risk factors for glaucoma is elevated intraocular pressure (IOP) and reduction in IOP… read more here.
Keywords: glaucoma like; like optic; iop; optic neuropathy ... See more keywords