Investigating the associations of mucosal P2Y6 receptor expression and urinary ATP and ADP concentrations, with symptoms of overactive bladder
Sign Up to like & getrecommendations! Published in 2020 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24322
Abstract: To characterize purinergic signaling in overactive bladder (OAB). read more here.
Keywords: overactive bladder; bladder; associations mucosal; p2y6 receptor ... See more keywords
A promising drug candidate for the treatment of glaucoma based on a P2Y6-receptor agonist
Sign Up to like & getrecommendations! Published in 2018 at "Purinergic Signalling"
DOI: 10.1007/s11302-018-9614-7
Abstract: Extracellular nucleotides can regulate the production/drainage of the aqueous humor via activation of P2 receptors, thus affecting the intraocular pressure (IOP). We evaluated 5-OMe-UDP(α-B), 1A, a potent P2Y6-receptor agonist, for reducing IOP and treating glaucoma.… read more here.
Keywords: receptor; treatment glaucoma; p2y6 receptor; receptor agonist ... See more keywords
Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y6 Receptor Agonists.
Sign Up to like & getrecommendations! Published in 2017 at "MedChemComm"
DOI: 10.1039/c7md00397h
Abstract: Both agonists and antagonists of the UDP-activated P2Y6 receptor (P2Y6R) have been proposed for therapeutic use, in conditions such as cancer, inflammation, neurodegeneration and diabetes. Uracil nucleotides containing a South-bicyclo[3.1.0]hexane ((S)-methanocarba) ring system in place… read more here.
Keywords: nucleotides containing; methanocarba ring; pyrimidine nucleotides; p2y6 receptor ... See more keywords
P2Y6 receptor‐dependent microglial phagocytosis of synapses mediates synaptic and memory loss in aging
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13761
Abstract: Aging causes loss of brain synapses and memory, and microglial phagocytosis of synapses may contribute to this loss. Stressed neurons can release the nucleotide UTP, which is rapidly converted into UDP, that in turn activates… read more here.
Keywords: microglial phagocytosis; p2y6 receptor; loss; phagocytosis synapses ... See more keywords
The Role of a Selective P2Y6 Receptor Antagonist, MRS2578, on the Formation of Angiotensin II-Induced Abdominal Aortic Aneurysms
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/1983940
Abstract: Objective The P2Y6 receptor has been shown to be involved in many cardiovascular diseases, including hypertension and atherosclerosis. The study is aimed at exploring the role of the P2Y6 receptor in Ang II-induced abdominal aortic… read more here.
Keywords: group; p2y6 receptor; ang; receptor ... See more keywords
Changes in P2Y6 receptor‐mediated vasoreactivity following focal and global ischemia
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15283
Abstract: Ischemia, both in the form of focal thromboembolic stroke and following subarachnoid hemorrhage (SAH), causes upregulation of vasoconstrictive receptor systems within the cerebral vasculature. Descriptions regarding changes in purinergic signaling following ischemia are lacking, especially… read more here.
Keywords: ischemia; vasoreactivity; p2y6 receptor; changes p2y6 ... See more keywords
Mechanisms of sympathoexcitation via P2Y6 receptors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1014284
Abstract: Many drugs used in cardiovascular therapy, such as angiotensin receptor antagonists and beta-blockers, may exert at least some of their actions through effects on the sympathetic nervous system, and this also holds true for e.g.,… read more here.
Keywords: p2y6 receptors; caccinh a01; p2y6 receptor; receptor ... See more keywords
Knockout of the P2Y6 Receptor Prevents Peri-Infarct Neuronal Loss after Transient, Focal Ischemia in Mouse Brain
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042304
Abstract: After stroke, there is a delayed neuronal loss in brain areas surrounding the infarct, which may in part be mediated by microglial phagocytosis of stressed neurons. Microglial phagocytosis of stressed or damaged neurons can be… read more here.
Keywords: p2y6 receptor; brain; loss; neuronal loss ... See more keywords
Knockout of Purinergic P2Y6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043800
Abstract: Nonalcoholic steatohepatitis (NASH) is a disease that progresses from nonalcoholic fatty liver (NAFL) and which is characterized by inflammation and fibrosis. The purinergic P2Y6 receptor (P2Y6R) is a pro-inflammatory Gq/G12 family protein-coupled receptor and reportedly… read more here.
Keywords: inflammation; purinergic p2y6; liver injury; p2y6 receptor ... See more keywords