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   Articles with "p300" as a keyword



Development of C646‐Based Proteolysis Targeting Chimeras Degraders of the Lysine Acetyltransferases CBP and p300

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recommendations! Published in 2025 at "Chemmedchem"

DOI: 10.1002/cmdc.202400792

Abstract: The alteration of the lysine acetyltransferase activity and protein–protein interactions of the transcriptional co‐activators CREB‐binding protein (CBP) and p300 is linked to the development of both solid and hematological cancers. To target both functions of… read more here.

Keywords: p300; development c646; cbp p300;
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P300‐mediated modulations in self–other processing under psychedelic psilocybin are related to connectedness and changed meaning: A window into the self–other overlap

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recommendations! Published in 2020 at "Human Brain Mapping"

DOI: 10.1002/hbm.25174

Abstract: The concept of self and self‐referential processing has a growing explanatory value in psychiatry and neuroscience, referring to the cognitive organization and perceptual differentiation of self‐stimuli in health and disease. Conditions in which selfhood loses… read more here.

Keywords: changed meaning; time; psilocybin; self ... See more keywords

An Online P300 Brain–Computer Interface Based on Tactile Selective Attention of Somatosensory Electrical Stimulation

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recommendations! Published in 2018 at "Journal of Medical and Biological Engineering"

DOI: 10.1007/s40846-018-0459-x

Abstract: PurposeP300 component of event related potentials in response to visual and auditory stimulation has been widely used in brain–computer interfaces (BCI). In clinical applications, tactile stimulus based on somatosensory electrical stimulation is an alternative for… read more here.

Keywords: online p300; somatosensory electrical; electrical stimulation; attention ... See more keywords

Decline of p300 contributes to cell senescence and growth inhibition of hUC-MSCs through p53/p21 signaling pathway.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.05.061

Abstract: Human umbilical cord-derived mesenchymal stromal cells (hUC-MSCs) in vitro expansion for long term may undergo epigenetic and genetic alterations that subsequently induce cellular senescence and associated growth inhibition. Increasing evidence implicated that aberrant histone acetylation modulates… read more here.

Keywords: p53 p21; huc mscs; senescence; inhibition ... See more keywords

O129 Intellectual functioning and P300 potential in adolescents with newly diagnosed multiple sclerosis

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recommendations! Published in 2017 at "Clinical Neurophysiology"

DOI: 10.1016/j.clinph.2017.07.140

Abstract: Objectives EBM literature offers no data on cognitive impairment in patients diagnosed with MS in childhood and adolescence. The aim of the study was to assess intellectual function in children and adolescents with MS. Methods… read more here.

Keywords: p300 potential; newly diagnosed; intellectual functioning; o129 intellectual ... See more keywords

Algorithmic clustering based on string compression to extract P300 structure in EEG signals

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recommendations! Published in 2019 at "Computer methods and programs in biomedicine"

DOI: 10.1016/j.cmpb.2019.03.009

Abstract: BACKGROUND AND OBJECTIVES P300 is an Event Related Potential control signal widely used in Brain Computer Interfaces. Using the oddball paradigm, a P300 speller allows a human to spell letters through P300 events produced by… read more here.

Keywords: algorithmic clustering; methodology; compression; structure ... See more keywords

Brd4 and P300 Confer Transcriptional Competency during Zygotic Genome Activation.

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recommendations! Published in 2019 at "Developmental cell"

DOI: 10.1016/j.devcel.2019.05.037

Abstract: The awakening of the genome after fertilization is a cornerstone of animal development. However, the mechanisms that activate the silent genome after fertilization are poorly understood. Here, we show that transcriptional competency is regulated by… read more here.

Keywords: genome activation; brd4; transcriptional competency; p300 ... See more keywords

Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.

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recommendations! Published in 2019 at "European journal of medicinal chemistry"

DOI: 10.1016/j.ejmech.2019.07.026

Abstract: p300 is an important histone acetyltransferase in epigenetics, and its overexpression is closely related to various diseases such as cancers. C646 is one of the most representative p300 inhibitors and used in various studies of… read more here.

Keywords: p300 inhibitors; histone acetyltransferase; activity; p300 ... See more keywords

Selective p300 inhibitor C646 inhibited HPV E6‐E7 genes, altered glucose metabolism and induced apoptosis in cervical cancer cells

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recommendations! Published in 2017 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2017.06.005

Abstract: &NA; High risk HPV infection is a causative factor of cervical cancer. The constitutive expression of HPV E6‐E7 genes is important for the maintenance of cancer phenotypes. The cellular transcription co‐activator p300 plays a crucial… read more here.

Keywords: c646 inhibited; cervical cancer; hpv genes; p300 ... See more keywords

Cognitive impairment in Chinese IIDDs revealed by MoCA and P300.

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recommendations! Published in 2017 at "Multiple sclerosis and related disorders"

DOI: 10.1016/j.msard.2017.05.006

Abstract: To investigate the value of MoCA and auditory P300 as a cognitive assessment tool in chinese idiopathic inflammatory-demyelinating diseases (IIDDs), eighty three consecutive patients with IIDDs and thirteen sex- and age-matched healthy controls were recruited… read more here.

Keywords: p300 cognitive; chinese iidds; moca; cognitive impairment ... See more keywords

Evaluation of flashing stimuli shape and colour heterogeneity using a P300 brain-computer interface speller

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recommendations! Published in 2019 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2019.134385

Abstract: Previous works using a visual P300-based speller have reported an improvement modifying the shape or colour of the presented stimulus. However, the effects of both blended factors have not been yet studied. Thus, the aim… read more here.

Keywords: colour heterogeneity; block shaped; speller; p300 ... See more keywords