Design, synthesis, and biological evaluation of a new class of histone acetyltransferase p300 inhibitors.
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DOI: 10.1016/j.ejmech.2019.07.026
Abstract: p300 is an important histone acetyltransferase in epigenetics, and its overexpression is closely related to various diseases such as cancers. C646 is one of the most representative p300 inhibitors and used in various studies of… read more here.
Keywords: p300 inhibitors; histone acetyltransferase; activity; p300 ... See more keywords
Current development of CBP/p300 inhibitors in the last decade.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112861
Abstract: CBP/p300, functioning as histone acetyltransferases and transcriptional co-factors, represents an attractive target for various diseases, including malignant tumor. The development of small-molecule inhibitors targeting the bromodomain and HAT domains of CBP/p300 has aroused broad interests… read more here.
Keywords: p300 inhibitors; cbp; development cbp; cbp p300 ... See more keywords