Neuronal Spleen tyrosine kinase (SYK) mediates cytokine release in Transgenic Tau P301S mice organotypic brain slice cultures
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DOI: 10.1016/j.neulet.2020.134992
Abstract: The Spleen Tyrosine Kinase (SYK) is known for its involvement in B-cell and T-cell signaling, modulating the peripheral immune response. We have previously shown that SYK is overactive in the brains of human Alzheimer's Disease… read more here.
Keywords: p301s mice; tau p301s; pathology; syk ... See more keywords
Effect of Nrf2 loss on senescence and cognition of tau-based P301S mice
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DOI: 10.1101/2022.10.31.514571
Abstract: Cellular senescence may contribute to chronic inflammation involved in the progression of age-related diseases such as Alzheimer’s disease (AD), and its removal prevents cognitive impairment in a model of tauopathy. Nrf2, the major transcription factor… read more here.
Keywords: tau; nrf2 loss; senescence; p301s mice ... See more keywords
Different modes of synaptic and extrasynaptic NMDA receptor alteration in the hippocampus of P301S tau transgenic mice
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DOI: 10.1111/bpa.13115
Abstract: N‐methyl‐d‐aspartate receptors (NMDARs) are pivotal players in the synaptic transmission and synaptic plasticity underlying learning and memory. Accordingly, dysfunction of NMDARs has been implicated in the pathophysiology of Alzheimer disease (AD). Here, we used histoblot… read more here.
Keywords: density; pathology; hippocampus p301s; p301s mice ... See more keywords
Alteration in the Synaptic and Extrasynaptic Organization of AMPA Receptors in the Hippocampus of P301S Tau Transgenic Mice
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DOI: 10.3390/ijms232113527
Abstract: Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies, but how pathological tau accumulation alters the glutamate receptor dynamics driving synaptic dysfunction is unclear. Here, we determined the impact of tau pathology… read more here.
Keywords: tau; pathology; hippocampus p301s; p301s mice ... See more keywords