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   Articles with "p32" as a keyword



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An approach to p32/gC1qR/HABP1: a multifunctional protein with an essential role in cancer

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recommendations! Published in 2022 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-022-04001-5

Abstract: P32/gC1qR/HABP1 is a doughnut-shaped acidic protein, highly conserved in eukaryote evolution and ubiquitous in the organism. Although its canonical subcellular localization is the mitochondria, p32 can also be found in the cytosol, nucleus, cytoplasmic membrane,… read more here.

Keywords: gc1qr habp1; cancer; p32; p32 gc1qr ... See more keywords

p32 heterozygosity protects against age- and diet-induced obesity by increasing energy expenditure

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-06209-9

Abstract: Obesity is increasing in prevalence and has become a global public health problem. The main cause of obesity is a perturbation in energy homeostasis, whereby energy intake exceeds energy expenditure. Although mitochondrial dysfunction has been… read more here.

Keywords: energy expenditure; p32; obesity increasing; energy ... See more keywords
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Arginase II protein regulates Parkin-dependent p32 degradation that contributes to Ca2+-dependent eNOS activation in endothelial cells.

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recommendations! Published in 2021 at "Cardiovascular research"

DOI: 10.1093/cvr/cvab163

Abstract: AIMS Arginase II (ArgII) plays a key role in the regulation of Ca2+ between the cytosol and mitochondria in a p32-dependent manner. p32 contributes to endothelial nitric oxide synthase (eNOS) activation through the Ca2+/CaMKII/AMPK/p38MAPK/Akt signaling… read more here.

Keywords: protein; argii; p32; enos activation ... See more keywords
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Heterozygous P32/C1QBP/HABP1 Polymorphism rs56014026 Reduces Mitochondrial Oxidative Phosphorylation and Is Expressed in Low-grade Colorectal Carcinomas

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recommendations! Published in 2020 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2020.631592

Abstract: Rapid proliferation of cancer cells is enabled by favoring aerobic glycolysis over mitochondrial oxidative phosphorylation (OXPHOS). P32 (C1QBP/gC1qR) is essential for mitochondrial protein translation and thus indispensable for OXPHOS activity. It is ubiquitously expressed and… read more here.

Keywords: p32 c1qbp; grade colorectal; p32; mitochondrial oxidative ... See more keywords
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Overexpression of Multifunctional Protein p32 Promotes a Malignant Phenotype in Colorectal Cancer Cells

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recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.642940

Abstract: p32 is a multifunctional and multicompartmental protein that has been found upregulated in numerous adenocarcinomas, including colorectal malignancy. High levels of p32 expression have been correlated with poor prognosis in colorectal cancer. However, the functions… read more here.

Keywords: colorectal cancer; p32; cancer cells; cancer ... See more keywords