A shift in chromatin binding of phosphorylated p38 precedes transcriptional changes upon oxidative stress
Sign Up to like & getrecommendations! Published in 2024 at "Febs Letters"
DOI: 10.1002/1873-3468.15006
Abstract: P38 mitogen‐activated protein kinases are key in the regulation of the cellular response to stressors. P38 is known to regulate transcription, mRNA processing, stability, and translation. The transcriptional changes mediated by phosphorylated p38 (P‐p38) in… read more here.
Keywords: phosphorylated p38; transcriptional changes; chromatin; oxidative stress ... See more keywords
Intermittent Fasting‐Induced Orm2 Promotes Adipose Browning via the GP130/IL23R‐p38 Cascade
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DOI: 10.1002/advs.202407789
Abstract: Intermittent fasting (IF) plays a critical role in mitigating obesity, yet the precise biological mechanisms require further elucidation. Here Orosomucoid 2 (Orm2) is identified as an IF‐induced hepatokine that stimulates adipose browning. IF induced Orm2… read more here.
Keywords: il23r; orm2; p38; gp130 il23r ... See more keywords
An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900303
Abstract: The mitogen‐activated protein kinase p38α pathway has been an attractive target for the treatment of inflammatory conditions such as rheumatoid arthritis. While a number of p38α inhibitors have been taken to the clinic, they have… read more here.
Keywords: prevention activation; activated protein; mk2; p38 ... See more keywords
Paeoniflorin attenuated bupivacaine‐induced neurotoxicity in SH‐SY5Y cells via suppression of the p38 MAPK pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27964
Abstract: Bupivacain, a common local anesthetic, can cause neurotoxicity and permanent neurological disorders. Paeoniflorin has been widely reported as a potential neuroprotective agent in neural injury models. However, the roles and molecular basis of paeoniflorin in… read more here.
Keywords: p38 mapk; p38; bupivacaine induced; sy5y cells ... See more keywords
Mapping p38α mitogen‐activated protein kinase signaling by proximity‐dependent labeling
Sign Up to like & getrecommendations! Published in 2020 at "Protein Science"
DOI: 10.1002/pro.3854
Abstract: Mitogen‐activated protein (MAP) kinase signaling is central to multiple cellular responses and processes. MAP kinase p38α is the best characterized member of the p38 MAP kinase family. Upstream factors and downstream targets of p38α have… read more here.
Keywords: kinase; activated protein; p38; map kinase ... See more keywords
Induced Pluripotent Stem Cells Regulate Triggering Receptor Expressed on Myeloid Cell‐1 Expression and the p38 Mitogen‐Activated Protein Kinase Pathway in Endotoxin‐Induced Acute Lung Injury
Sign Up to like & getrecommendations! Published in 2019 at "STEM CELLS"
DOI: 10.1002/stem.2980
Abstract: Induced pluripotent stem cells (iPSCs) can attenuate the pathological severity and neutrophil migration of lipopolysaccharide (LPS)‐induced acute lung injury (ALI). However, interactions that may occur between iPSCs and the triggering receptor expressed on myeloid cells… read more here.
Keywords: stem cells; p38; expression; trem ... See more keywords
Aquaporin-1 attenuates macrophage-mediated inflammatory responses by inhibiting p38 mitogen-activated protein kinase activation in lipopolysaccharide-induced acute kidney injury
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation Research"
DOI: 10.1007/s00011-019-01285-1
Abstract: This study was designed to investigate the role of AQP1 in the development of LPS-induced AKI and its potential regulatory mechanisms in the inflammatory responses of macrophages. Male Wistar rats were injected intraperitoneally with LPS,… read more here.
Keywords: p38 mapk; inflammatory responses; macrophage mediated; p38 ... See more keywords
LPS-induced autophagy in human dental pulp cells is associated with p38.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular histology"
DOI: 10.1007/s10735-021-10004-2
Abstract: Lipopolysaccharides (LPS), which are components of the cell wall of Gram-negative bacteria, are among the important factors that induce inflammation, including pulpitis. Autophagy in human dental pulp cells (hDPCs) acts as a protective mechanism that… read more here.
Keywords: autophagy human; lps induced; human dental; p38 ... See more keywords
p38 Inhibition Ameliorates Inspiratory Resistive Breathing-Induced Pulmonary Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0831-6
Abstract: Inspiratory resistive breathing (IRB), a hallmark of obstructive airway diseases, is associated with strenuous contractions of the inspiratory muscles and increased negative intrathoracic pressures that act as an injurious stimulus to the lung. We have… read more here.
Keywords: pulmonary inflammation; inspiratory resistive; induced pulmonary; inflammation ... See more keywords
1,25-Dihydroxy Vitamin D3 Attenuates the Oxidative Stress-Mediated Inflammation Induced by PM2.5via the p38/NF-κB/NLRP3 Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation"
DOI: 10.1007/s10753-018-0928-y
Abstract: Vitamin D3 is reported to be involved in the regulation of inflammatory processes. In this study, biomarkers related to oxidative stress and inflammation were investigated to clarify the protective effects and possible mechanism of 1,25-dihydroxy… read more here.
Keywords: induced pm2; inflammation; p38; vitamin ... See more keywords
Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-020-00948-w
Abstract: Go-sha-jinki-Gan (GJG) is a traditional Japanese herbal medicine. In clinical practice, GJG is effective against neuropathic pain and hypersensitivity induced by chemotherapy or diabetes. In our previous study using a chronic constriction injury mouse model,… read more here.
Keywords: p38 tnf; tnf; tnf signaling; nervous system ... See more keywords