LAUSR

IFN‐γ stimulates CpG‐induced IL‐10 production in B cells via p38 and JNK signalling pathways

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1 Published in 2018 at "European Journal of Immunology"

DOI: 10.1002/eji.201847578

Abstract: The production of IL‐10, a potent immunosuppressive cytokine, must be strictly regulated to ensure a balanced immune response. IFN‐γ, a key cytokine in multiple immune processes and pathologies, is known as an inhibitor of IL‐10… read more here.

Keywords: p38 jnk; production; induced production; ifn ... See more keywords

Tumor necrosis factor alpha-stimulated gene-6 (TSG-6) inhibits the inflammatory response by inhibiting the activation of P38 and JNK signaling pathway and decreases the restenosis of vein grafts in rats

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1 Published in 2017 at "Heart and Vessels"

DOI: 10.1007/s00380-017-1059-3

Abstract: This study aims to explore the effects of tumor necrosis factor alpha-stimulated gene-6 (TSG-6) on vascular inflammatory response and vascular injury in grafted vein wall of rats and its possible mechanism. Vascular grafting model was… read more here.

Keywords: p38 jnk; jnk; tsg; inflammatory response ... See more keywords

Phorbol esters induce PLVAP expression via VEGF and additional secreted molecules in MEK1‐dependent and p38, JNK and PI3K/Akt‐independent manner

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1 Published in 2019 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.13993

Abstract: Endothelial diaphragms are subcellular structures critical for mammalian survival with poorly understood biogenesis. Plasmalemma vesicle associated protein (PLVAP) is the only known diaphragm component and is necessary for diaphragm formation. Very little is known about… read more here.

Keywords: p38 jnk; manner; induce plvap; expression ... See more keywords

Royal Jelly Attenuates LPS-Induced Inflammation in BV-2 Microglial Cells through Modulating NF-κB and p38/JNK Signaling Pathways

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1 Published in 2018 at "Mediators of Inflammation"

DOI: 10.1155/2018/7834381

Abstract: Royal jelly (RJ), a hive product with versatile pharmacological activities, has been used as a traditional functional food to prevent or treat inflammatory diseases. However, little is known about the anti-inflammatory effect of RJ in… read more here.

Keywords: p38 jnk; microglial cells; lps induced; royal jelly ... See more keywords

Icariin induces cell differentiation and cell cycle arrest in mouse melanoma B16 cells via Erk1/2-p38-JNK-dependent pathway

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1 Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.20118

Abstract: Icariin (ICA) is a major component isolated from Epimedium brevicornum. Emerging evidence shows that ICA can inhibit tumor cell proliferation, invasion and migration. However, the anti-cancer effect of ICA on B16 cells has not been… read more here.

Keywords: p38 jnk; b16; cell; erk1 p38 ... See more keywords

Human and mouse TLR2 results in different activation of p38 and JNK signal pathway in HaCaT infected by Trichophyton rubrum and Microsporum canis

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3 Published in 2023 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.1063443

Abstract: Introduction It has long been recognized that inflammation to dermatophyte infection is different among various hosts, but the mechanism underlying is still not well understood. Toll-like receptor (TLR2), mediates the innate immune response against dermatophyte… read more here.

Keywords: p38 jnk; rubrum; hacat; tlr2 ... See more keywords

Canagliflozin Delays Aging of HUVECs Induced by Palmitic Acid via the ROS/p38/JNK Pathway

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1 Published in 2023 at "Antioxidants"

DOI: 10.3390/antiox12040838

Abstract: Vascular aging is an important factor contributing to cardiovascular diseases, such as hypertension and atherosclerosis. Hyperlipidemia or fatty accumulation may play an important role in vascular aging and cardiovascular diseases. Canagliflozin (CAN), a sodium-glucose cotransporter… read more here.

Keywords: p38 jnk; ros p38; jnk pathway; induced palmitic ... See more keywords

Inhibition of Phosphodiesterase 4 by FCPR03 Alleviates Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice: Involvement of p38 and JNK Signaling Pathways

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0 Published in 2018 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms19020513

Abstract: Inflammatory responses induced by peripheral administration of lipopolysaccharide (LPS) triggers depressive-like behavioral syndrome in rodents. Inhibition of phosphodiesterase 4 (PDE4) produces a robust anti-inflammatory effect in inflammatory cells. Unfortunately, archetypal PDE4 inhibitors cause intolerable gastrointestinal… read more here.

Keywords: p38 jnk; fcpr03; inhibition phosphodiesterase; p38 ... See more keywords

Tea Polyphenols Protect the Mammary Gland of Dairy Cows by Enhancing Antioxidant Capacity and Regulating the TGF-β1/p38/JNK Pathway

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2 Published in 2022 at "Metabolites"

DOI: 10.3390/metabo12111009

Abstract: Tea polyphenols (TPs) are the main active substances in tea and they have many beneficial effects, such as anti-inflammation, antioxidant, anti-cancer and metabolic regulation effects. The quality of milk is affected by mammary gland diseases… read more here.

Keywords: gland; p38 jnk; tea polyphenols; mammary gland ... See more keywords

Protective Effects of Astragaloside IV against LPS-Induced Endometritis in Mice through Inhibiting Activation of the NF-κB, p38 and JNK Signaling Pathways

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1 Published in 2019 at "Molecules"

DOI: 10.3390/molecules24020373

Abstract: Endometritis, inflammation of the endometrium, is a common reproductive obstacle disease that can lead to infertility in female animals. Astragaloside IV (AS IV), one of the major and active components of the Astragalus membranaceus (Fisch.)… read more here.

Keywords: p38 jnk; signaling pathways; endometritis; lps induced ... See more keywords

Bavachinin Induces Oxidative Damage in HepaRG Cells through p38/JNK MAPK Pathways

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1 Published in 2018 at "Toxins"

DOI: 10.3390/toxins10040154

Abstract: Drug-induced liver injury is one of the main causes of drug non-approval and drug withdrawal by the Food and Drug Administration (FDA). Bavachinin (BVC) is a natural product derived from the fruit of the traditional… read more here.

Keywords: p38 jnk; jnk; oxidative damage; drug ... See more keywords