Ghrelin modulates intracellular signalling pathways that are critical for podocyte survival
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3397
Abstract: Damage to podocytes is a key event in glomerulopathies. While energy dense food can contribute to kidney damage, the role of the orixegenic hormone “ghrelin” in podocyte biology is still unknown. In the present study,… read more here.
Keywords: p38 mapk; podocyte survival; ghrelin;
FCRL3 promotes IL-10 expression in B cells through the SHP-1 and p38 MAPK signalling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biology international"
DOI: 10.1002/cbin.11373
Abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is caused by the interaction of genetic and environmental factors. Current studies have shown that FCRL3 is closely related to MS, but… read more here.
Keywords: p38 mapk; secretion; fcrl3; shp p38 ... See more keywords
TNF-α regulates the early development of avascular necrosis of femoral head by mediating osteoblast autophagy and apoptosis via p38 MAPK/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biology international"
DOI: 10.1002/cbin.11394
Abstract: Previous studies have shown that the tumor necrosis factor-α (TNF-α) levels in serum and bone tissues form avascular necrosis of femoral head (ANFH) patients were higher than that of normal individuals, indicating TNF-α might play… read more here.
Keywords: p38 mapk; autophagy apoptosis; tnf; apoptosis ... See more keywords
RAD23B mediated proteasomal degradation occurs through p38 MAPK/ATF‐2/RAD23B axis under nutrient‐deprived conditions in breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12160
Abstract: Metabolic reprogramming in cancer occurs due to interaction of cells with the surrounding tumor microenvironment. In the microenvironment of solid tumors, nutrient deprivation is induced by high consumption of nutrients and insufficient vasculature. Tumor cells… read more here.
Keywords: p38 mapk; cancer; breast cancer; atf rad23b ... See more keywords
Involvement of matrix metalloproteinase 1 and urokinase-type plasminogen activator in the PKCα-p38 MAPK pathway-mediated progression of human liver cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22057
Abstract: Our previous studies have shown that the plasminogen activator (PA) and matrix metalloproteinases (MMPs) proteinase systems were highly expressed in highly malignant liver cancer cells and regulated by PKCα. This study investigates whether the PKCα… read more here.
Keywords: liver cancer; cancer cells; p38 mapk;
Resveratrol Mitigates Acetamiprid‐Induced Cardiotoxicity in Rats via Modulation of Jak/Stat, p38 Mapk and mTOR Signaling Pathways
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70321
Abstract: Acetamiprid (ACP) is a novel neonicotinoid insecticide used frequently to eradicate insect pests. Resveratrol (RSV) is a polyphenol used as a potential antioxidant, anti‐inflammatory and antiapoptotic compound. The current research aimed to investigate the modulation… read more here.
Keywords: signaling pathways; stat p38; p38 mapk; mtor ... See more keywords
Paeoniflorin attenuated bupivacaine‐induced neurotoxicity in SH‐SY5Y cells via suppression of the p38 MAPK pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27964
Abstract: Bupivacain, a common local anesthetic, can cause neurotoxicity and permanent neurological disorders. Paeoniflorin has been widely reported as a potential neuroprotective agent in neural injury models. However, the roles and molecular basis of paeoniflorin in… read more here.
Keywords: p38 mapk; p38; bupivacaine induced; sy5y cells ... See more keywords
Exploring the Therapeutic Potential of BBB‐Penetrating Phytochemicals With p38 MAPK Modulatory Activity in Addressing Oxidative Stress‐Induced Neurodegenerative Disorders, With a Focus on Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8329
Abstract: Oxidative stress plays an important role in the occurrence of neurodegenerative diseases. Previous studies indicate a strong connection between oxidative stress, inappropriate activation of the p38 MAPK signaling pathway, and the pathogenesis of neurodegenerative diseases.… read more here.
Keywords: bbb penetrating; oxidative stress; p38 mapk; neurodegenerative disorders ... See more keywords
SPARC promotes self‐renewal of limbal epithelial stem cells and ocular surface restoration through JNK and p38‐MAPK signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "STEM CELLS"
DOI: 10.1002/stem.3100
Abstract: The purpose of this study was to investigate the effects of secreted protein acidic and rich in cysteine (SPARC) on the maintenance of limbal epithelial stem cell (LESC) stemness and restoration of ocular surface. To… read more here.
Keywords: p38 mapk; signaling pathways; sparc; jnk p38 ... See more keywords
LncRNA MEG3 ameliorates NiO nanoparticles‐induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23464
Abstract: The lung inflammatory damage could result from the nickel oxide nanoparticles (NiO NPs), in which the underlying mechanism is still unclear. This article explored the roles of long noncoding RNA maternally expressed gene 3 (lncRNA… read more here.
Keywords: inflammatory damage; nio nps; lncrna meg3; mapk pathway ... See more keywords
Selenium nanoparticles improve nickel-induced testosterone synthesis disturbance by down-regulating miR-708-5p/p38 MAPK pathway in Leydig cells.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23811
Abstract: The present study was designed to investigate the role of miR-708-5p/p38 mitogen-activated protein kinase (MAPK) pathway during the mechanism of selenium nanoparticles (Nano-Se) against nickel (Ni)-induced testosterone synthesis disorder in rat Leydig cells. We conducted… read more here.
Keywords: mir 708; leydig cells; p38 mapk; testosterone synthesis ... See more keywords