Ghrelin modulates intracellular signalling pathways that are critical for podocyte survival
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3397
Abstract: Damage to podocytes is a key event in glomerulopathies. While energy dense food can contribute to kidney damage, the role of the orixegenic hormone “ghrelin” in podocyte biology is still unknown. In the present study,… read more here.
Keywords: p38 mapk; podocyte survival; ghrelin;
FCRL3 promotes IL-10 expression in B cells through the SHP-1 and p38 MAPK signalling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biology international"
DOI: 10.1002/cbin.11373
Abstract: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is caused by the interaction of genetic and environmental factors. Current studies have shown that FCRL3 is closely related to MS, but… read more here.
Keywords: p38 mapk; secretion; fcrl3; shp p38 ... See more keywords
TNF-α regulates the early development of avascular necrosis of femoral head by mediating osteoblast autophagy and apoptosis via p38 MAPK/NF-κB signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Cell biology international"
DOI: 10.1002/cbin.11394
Abstract: Previous studies have shown that the tumor necrosis factor-α (TNF-α) levels in serum and bone tissues form avascular necrosis of femoral head (ANFH) patients were higher than that of normal individuals, indicating TNF-α might play… read more here.
Keywords: p38 mapk; autophagy apoptosis; tnf; apoptosis ... See more keywords
Involvement of matrix metalloproteinase 1 and urokinase-type plasminogen activator in the PKCα-p38 MAPK pathway-mediated progression of human liver cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22057
Abstract: Our previous studies have shown that the plasminogen activator (PA) and matrix metalloproteinases (MMPs) proteinase systems were highly expressed in highly malignant liver cancer cells and regulated by PKCα. This study investigates whether the PKCα… read more here.
Keywords: liver cancer; cancer cells; p38 mapk;
Paeoniflorin attenuated bupivacaine‐induced neurotoxicity in SH‐SY5Y cells via suppression of the p38 MAPK pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27964
Abstract: Bupivacain, a common local anesthetic, can cause neurotoxicity and permanent neurological disorders. Paeoniflorin has been widely reported as a potential neuroprotective agent in neural injury models. However, the roles and molecular basis of paeoniflorin in… read more here.
Keywords: p38 mapk; p38; bupivacaine induced; sy5y cells ... See more keywords
SPARC promotes self‐renewal of limbal epithelial stem cells and ocular surface restoration through JNK and p38‐MAPK signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "STEM CELLS"
DOI: 10.1002/stem.3100
Abstract: The purpose of this study was to investigate the effects of secreted protein acidic and rich in cysteine (SPARC) on the maintenance of limbal epithelial stem cell (LESC) stemness and restoration of ocular surface. To… read more here.
Keywords: p38 mapk; signaling pathways; sparc; jnk p38 ... See more keywords
LncRNA MEG3 ameliorates NiO nanoparticles‐induced pulmonary inflammatory damage via suppressing the p38 mitogen activated protein kinases pathway
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23464
Abstract: The lung inflammatory damage could result from the nickel oxide nanoparticles (NiO NPs), in which the underlying mechanism is still unclear. This article explored the roles of long noncoding RNA maternally expressed gene 3 (lncRNA… read more here.
Keywords: inflammatory damage; nio nps; lncrna meg3; mapk pathway ... See more keywords
Selenium nanoparticles improve nickel-induced testosterone synthesis disturbance by down-regulating miR-708-5p/p38 MAPK pathway in Leydig cells.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23811
Abstract: The present study was designed to investigate the role of miR-708-5p/p38 mitogen-activated protein kinase (MAPK) pathway during the mechanism of selenium nanoparticles (Nano-Se) against nickel (Ni)-induced testosterone synthesis disorder in rat Leydig cells. We conducted… read more here.
Keywords: mir 708; leydig cells; p38 mapk; testosterone synthesis ... See more keywords
Aquaporin-1 attenuates macrophage-mediated inflammatory responses by inhibiting p38 mitogen-activated protein kinase activation in lipopolysaccharide-induced acute kidney injury
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation Research"
DOI: 10.1007/s00011-019-01285-1
Abstract: This study was designed to investigate the role of AQP1 in the development of LPS-induced AKI and its potential regulatory mechanisms in the inflammatory responses of macrophages. Male Wistar rats were injected intraperitoneally with LPS,… read more here.
Keywords: p38 mapk; inflammatory responses; macrophage mediated; p38 ... See more keywords
Dual immuno-renal targeting of 7-benzylidenenaltrexone alleviates lupus nephritis via FcγRIIB and HO-1
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-018-1626-9
Abstract: Known as a selective δ1 opioid receptor (DOR1) antagonist, the 7-benzylidenenaltrexone (BNTX) is also a DOR1-independent immunosuppressant with unknown mechanisms. Here we investigated if BNTX could be beneficial for diseased MRL/lpr lupus mice. We treated… read more here.
Keywords: p38 mapk; benzylidenenaltrexone; via riib; lupus nephritis ... See more keywords
Angiopoietin-like 2 upregulation promotes human chondrocyte injury via NF-κB and p38/MAPK signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-019-01016-w
Abstract: Several cellular and molecular processes participate in the pathologic changes of osteoarthritis (OA). However, the core molecular regulators of these processes are unclear, and no effective treatment for OA disease has been developed so far.… read more here.
Keywords: p38 mapk; upregulation promotes; mapk signaling; human chondrocytes ... See more keywords