A Comprehensive Structural Overview of p38α Mitogen‐Activated Protein Kinase in Complex with ATP‐Site and Non‐ATP‐Site Binders
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DOI: 10.1002/cmdc.201700636
Abstract: Herein we review all the currently available ATP‐site and non‐ATP‐site ligands bound to p38α mitogen‐activated protein kinase (MAPK) available in the RCSB Protein Data Bank (PDB). The co‐crystallized inhibitors have been classified into different families… read more here.
Keywords: atp site; site non; p38 mitogen; site ... See more keywords
Perineural invasion is related to p38 mitogen‐activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28457
Abstract: Metastasis is a key component of cancer progression and is strongly associated with poor prognosis. Perineural invasion is thought to be related to pain, tumor recurrence, and other conditions. However, the exact molecular mechanism is… read more here.
Keywords: perineural invasion; pancreatic cancer; p38 mitogen; cancer ... See more keywords
Static magnetic fields enhance dental pulp stem cell proliferation by activating the p38 mitogen‐activated protein kinase pathway as its putative mechanism
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2333
Abstract: Dental pulp stem cells (DPSCs) can be a potential stem cell resource for clinical cell therapy and tissue engineering. However, obtaining a sufficient number of DPSCs for repairing defects is still an issue in clinical… read more here.
Keywords: activated protein; p38 mitogen; proliferation; cell ... See more keywords
Thymoquinone induces apoptosis in temozolomide‐resistant glioblastoma cells via the p38 mitogen‐activated protein kinase signaling pathway
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DOI: 10.1002/tox.23664
Abstract: Temozolomide (TMZ) can cross the blood‐brain barrier (BBB) and deliver methyl groups to the purine (guanine) bases of DNA, leading to mispairing during DNA replication and subsequent cell death. However, increased expression of the repair… read more here.
Keywords: mitogen activated; protein kinase; activated protein; p38 mitogen ... See more keywords
p38 mitogen-activated protein kinases (MAPKs) are involved in intestinal immune response to bacterial muramyl dipeptide challenge in Ctenopharyngodon idella.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.12.007
Abstract: The p38 mitogen-activated protein kinases (MAPKs) are essential cytoplasmic signal molecules of innate immune pathways that play a vital role in host immune defense responses to pathogenic challenges. In this study, two fish p38 genes… read more here.
Keywords: dipeptide; cip38; p38 mitogen; p38 ... See more keywords
An isoform-selective p38α mitogen-activated protein kinase inhibitor rescues early entorhinal cortex dysfunctions in a mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.06.006
Abstract: Neuroinflammation is a fundamental mechanism in Alzheimer's disease (AD) progression. The stress-induced activation of the p38α mitogen-activated protein kinase (MAPK) leads to increased production of proinflammatory cytokines and neurodegeneration. We investigated the effects of an… read more here.
Keywords: inhibitor; alzheimer disease; p38 mitogen; activated protein ... See more keywords
An Effective Antiviral Approach Targeting Hepatitis B Virus with NJK14047, a Novel and Selective Biphenyl Amide p38 Mitogen-Activated Protein Kinase Inhibitor
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DOI: 10.1128/aac.00214-17
Abstract: ABSTRACT Despite recent advances in therapeutic strategies against hepatitis B virus (HBV) infection, chronic hepatitis B remains a major global health burden. Recent studies have shown that targeting host factors instead of viral factors can… read more here.
Keywords: hbv; effective antiviral; p38 mitogen; p38 ... See more keywords
Effects of VCP979 Novel p38 Mitogen Activated Protein Kinase Inhibitor on Progression of Pancreatic Cancer in Mouse Model with Diabetic Conditions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biomedical nanotechnology"
DOI: 10.1166/jbn.2019.2775
Abstract: Pancreatic cancer is a highly lethal tumor that is characterized by a marked fibro-inflammatory microenvironment, presence of which can promote cancer progression. Few therapeutic options exist for pancreatic cancer, thus identification of pathways for targeting… read more here.
Keywords: pancreatic cancer; p38 mitogen; protein kinase; cancer ... See more keywords
Effect of the p38 Mitogen-Activated Protein Kinase Signaling Cascade on Radiation Biodosimetry
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DOI: 10.1667/rade-21-00240.1
Abstract: Radiation biodosimetry based on transcriptomic analysis of peripheral blood is a valuable tool to detect radiation exposure after a radiological/nuclear event and obtain useful biological information that could predict tissue and organismal injury. However, confounding… read more here.
Keywords: mitogen activated; p38 mitogen; radiation biodosimetry; radiation ... See more keywords
Integration of In Silico Strategies for Drug Repositioning towards P38α Mitogen-Activated Protein Kinase (MAPK) at the Allosteric Site
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DOI: 10.3390/pharmaceutics14071461
Abstract: P38α mitogen-activated protein kinase (p38α MAPK), one of the p38 MAPK isoforms participating in a signaling cascade, has been identified for its pivotal role in the regulation of physiological processes such as cell proliferation, differentiation,… read more here.
Keywords: mitogen activated; p38 mitogen; activated protein; p38 mapk ... See more keywords