Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112451
Abstract: We report the design of hetero-bifunctional small molecules that selectively target p38α and p38β for degradation. These proteolysis targeted chimeras (PROTACs) are based on an ATP competitive inhibitor of p38α and p38β, which is linked… read more here.
Keywords: degradation; target p38; protacs; p38 p38 ... See more keywords
The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18264
Abstract: By gating the traffic of molecules and cells across the vessel wall, endothelial cells play a central role in regulating cardiovascular functions and systemic homeostasis and in modulating pathophysiological processes such as inflammation and immunity.… read more here.
Keywords: p38; endothelial cells; stress metastatic; p38 p38 ... See more keywords
p38γ and p38δ Are Involved in T Lymphocyte Development
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00065
Abstract: p38 mitogen-activated protein kinase (MAPK) signal transduction pathways are essential regulators of the immune response. Particularly, p38γ and p38δ regulate many immune cell functions such as cytokine production, migration, or T cell activation; however, their… read more here.
Keywords: cd4 cd8; p38; p38 p38; cell ... See more keywords