IL‐17A contributes to myocardial ischemic injury by activating NLRP3 inflammasome in macrophages through AMPK&agr;/p38MAPK/ERK1/2 signal pathway in mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.12.014
Abstract: Background Acute myocardial infarction (AMI) is followed by an acute inflammation involving inflammasome activation, thereby inducing cardiac dysfunction. Interleukin‐17A (IL‐17A) involves in many inflammatory diseases, but its roles in inflammation following AMI are still obscure.… read more here.
Keywords: myocardial ischemic; ampk agr; p38mapk erk1; agr p38mapk ... See more keywords
Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14866
Abstract: ADAMTS18 is a novel tumor suppressor and is critical to the pathology of human colorectal cancer. However, the underlying mechanism is not clear. Here we generated an Adamts18-deficient mouse strain as an in vivo model… read more here.
Keywords: p38mapk erk1; colorectal cancer; cancer; adamts18 deficiency ... See more keywords