Structural comparison of the cytochrome P450 enzymes CYP106A1 and CYP106A2 provides insight into their differences in steroid conversion
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DOI: 10.1002/1873-3468.14502
Abstract: Understanding the structural basis of the selectivity of steroid hydroxylation requires detailed structural and functional investigations on various steroid hydroxylases with different selectivities, such as the bacterial cytochrome P450 enzymes. Here, the crystal structure of… read more here.
Keywords: p450; cytochrome p450; p450 enzymes; structural comparison ... See more keywords
Whole‐Cell P450 Biocatalysis Using Engineered Escherichia coli with Fine‐Tuned Heme Biosynthesis (Adv. Sci. 6/2023)
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DOI: 10.1002/advs.202205580
Abstract: By exploiting versatile P450 enzymes, whole‐cell biocatalysis can be performed to synthesize valuable compounds in Escherichia coli. However, the insufficient supply of heme limits the whole‐cell P450 biocatalytic activity. Here a strategy for improving intracellular… read more here.
Keywords: biosynthesis; fine tuned; heme biosynthesis; whole cell ... See more keywords
Biocatalytical Asymmetric Sulfoxidation by Identifying Cytochrome P450 from Parvibaculum Lavamentivorans DS‐1
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DOI: 10.1002/cctc.201801139
Abstract: Cytochrome P450 monooxygenases (P450s) catalyzed asymmetric sulfoxidation represents a green route for the synthesis of valuable enantiopure sulfoxides, which are potentially interesting synthons in synthetic and pharmaceutical chemistry. Here the potential P450 and redox partner… read more here.
Keywords: parvibaculum lavamentivorans; biocatalytical asymmetric; asymmetric sulfoxidation; p450 ... See more keywords
Deltamethrin is metabolized by CYP6FU1, a cytochrome P450 associated with pyrethroid resistance, in Laodelphax striatellus.
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DOI: 10.1002/ps.4808
Abstract: BACKGROUND Cytochrome P450s (CYPs) are known to play a major role in metabolizing a wide range compounds. CYP6FU1 has been found to be over-expressed in a deltamethrin-resistant strain of Laodelphax striatellus. This study was conducted… read more here.
Keywords: laodelphax striatellus; cytochrome; resistance; p450 ... See more keywords
Nuclear receptor HR96 upregulates cytochrome P450 for insecticide detoxification in Tribolium castaneum.
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DOI: 10.1002/ps.6626
Abstract: BACKGROUND Red flour beetle, Tribolium castaneum, is a major agricultural pest that causes significant damage to stored grains and products. Although hormone receptor 96 (HR96) is known to be the single ortholog corresponding to mammalian… read more here.
Keywords: hr96; tribolium; castaneum; p450 ... See more keywords
Functional investigation of lncRNAs and target cytochrome P450 genes related to spirotetramat resistance in Aphis gossypii Glover.
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DOI: 10.1002/ps.6818
Abstract: BACKGROUND Spirotetramat is a tetramic acid derivative insecticide with novel modes of action for controlling Aphis gossypii Glover in the field. Previous studies have shown that long noncoding RNAs (lncRNAs) and cytochrome P450 monooxygenases (P450s)… read more here.
Keywords: gossypii; cyp6cy21; spirotetramat resistance; expression ... See more keywords
Uncoupler SYP-14288 inducing multidrug resistance of Phytophthora capsici through overexpression of cytochrome P450 monooxygenases and P-glycoprotein.
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DOI: 10.1002/ps.6845
Abstract: BACKGROUND Fungicide resistance has become a serious problem for different mode of action groups except for uncouplers, which makes their resistance mechanism a hot topic. Until now, it has not been well clarified. SYP-14288, a… read more here.
Keywords: syp 14288; multidrug resistance; phytophthora capsici; p450 ... See more keywords
Adipokinetic hormone signaling regulates cytochrome P450-mediated chlorantraniliprole sensitivity in Spodoptera frugiperda (Lepidoptera: Noctuidae).
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DOI: 10.1002/ps.6896
Abstract: BACKGROUND Fall armyworm (FAW) is one of the most destructive and invasive pests worldwide and causes significant economic losses. Intensive and frequent use of insecticides has led to the development of resistance in FAW. Adipokinetic… read more here.
Keywords: expression; faw; resistance; faw chlorantraniliprole ... See more keywords
Three cytochrome P450 CYP4 family genes regulated by the CncC signaling pathway mediate phytochemical susceptibility in the red flour beetle, Tribolium castaneum.
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DOI: 10.1002/ps.6991
Abstract: BACKGROUND Insect cytochrome P450 monooxygenases (P450s) play a crucial role in phytochemical metabolism and tolerance. Three P450 genes (TcCYP4Q3, TcCYP4Q5, TcCYP4Q7) are associated with the response of eugenol in Tribolium castaneum. However, the responding mechanisms… read more here.
Keywords: signaling pathway; cncc signaling; p450 genes; cncc ... See more keywords
Activation of CncC pathway is involved in the regulation of P450 genes responsible for clothianidin resistance in Bradysia odoriphaga.
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DOI: 10.1002/ps.7482
Abstract: BACKGROUND Insect cytochrome P450 monooxygenases (P450s) play a key role in the detoxification metabolism of insecticides and their overexpression is often associated with insecticide resistance. Our previous research showed that the overexpression of four P450… read more here.
Keywords: clothianidin resistance; clothianidin; cncc; expression ... See more keywords
Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice
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DOI: 10.1007/s00204-018-2162-7
Abstract: Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s. In the present study, Hepatic Reductase Null (HRN) and Hepatic… read more here.
Keywords: mice; p450; cytochrome p450; bap ... See more keywords