Enhanced Activity and Substrate Specificity by Site‐Directed Mutagenesis for the P450 119 Peroxygenase Catalyzed Sulfoxidation of Thioanisole
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DOI: 10.1002/open.201900157
Abstract: Abstract P450 119 peroxygenase was found to catalyze the sulfoxidation of thioanisole and the sulfonation of sulfoxide in the presence of tert‐butyl hydroperoxide (TBHP) for the first time with turnover rates of 1549 min−1 and 196 min−1… read more here.
Keywords: thioanisole; 119 peroxygenase; p450 119; sulfoxidation thioanisole ... See more keywords
Resonance Raman spectroscopic studies of peroxo and hydroperoxo intermediates in lauric acid (LA)-bound cytochrome P450 119.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111084
Abstract: Cytochromes P450 bind and cleave dioxygen to generate a potent intermediate compound I, capable of hydroxylating inert hydrocarbon substrates. Cytochrome P450 119, a bacterial cytochrome P450 that serves as a good model system for the… read more here.
Keywords: lauric acid; p450; peroxo hydroperoxo; cytochrome p450 ... See more keywords