Mechanism of Cytochrome P450 17A1-Catalyzed Hydroxylase and Lyase Reactions
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DOI: 10.1021/acs.jcim.6b00759
Abstract: Cytochrome P450 17A1 (CYP17A1) catalyzes C17 hydroxylation of pregnenolone and progesterone and the subsequent C17-C20 bond cleavage (lyase reaction) to form androgen precursors. Compound I (Cpd I) and peroxo anion (POA) are the heme-reactive species… read more here.
Keywords: hydroxylase lyase; p450 17a1; reaction; lyase ... See more keywords
Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1
Sign Up to like & getrecommendations! Published in 2017 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.075317
Abstract: Human steroidogenic cytochrome P450 17A1 (CYP17A1) is a bifunctional enzyme that performs both hydroxylation and lyase reactions, with the latter required to generate androgens that fuel prostate cancer proliferation. The steroid abiraterone, the active form… read more here.
Keywords: functional evaluation; nonsteroidal inhibitors; structural functional; p450 17a1 ... See more keywords
Discovery of Novel Non-Steroidal Cytochrome P450 17A1 Inhibitors as Potential Prostate Cancer Agents
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DOI: 10.3390/ijms21144868
Abstract: The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other steroids, and it is implicated… read more here.
Keywords: cancer; p450 17a1; cytochrome p450; prostate cancer ... See more keywords