2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22
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DOI: 10.1080/00498254.2023.2197037
Abstract: Abstract The 2-oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole (a contributor to boar taint) mediated by minipig liver microsomes and recombinant P450 enzymes expressed in bacterial membranes were investigated. At low substrate concentrations of 10 µM,… read more here.
Keywords: p450 1a2; liver; liver microsomes; hydroxylation ... See more keywords
Correlation between assessment of cytochrome P450 1A2 activity and enzyme activity scores, and their relation to clozapine exposure
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DOI: 10.1111/bcp.15636
Abstract: Cytochrome P450 1A2 (CYP1A2) is involved in the metabolism of antipsychotic drugs such as clozapine and olanzapine. Personalization of these treatments requires an accurate estimation of CYP1A2 activity. In this study, we aimed (1) to… read more here.
Keywords: p450 1a2; cytochrome p450; activity; correlation ... See more keywords
Impact of Transgenic Arabidopsis thaliana Plants on Herbicide Isoproturon Phytoremediation through Expressing Human Cytochrome P450-1A2
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DOI: 10.3390/biology9110362
Abstract: Simple Summary Isoproturon is one of the best selective herbicide for weed control. Excessive use of herbicides causes many environmental problems. In the present study, phytoremediation of phenylurea isoproturon herbicide using transgenic A. thaliana plants… read more here.
Keywords: isoproturon; p450 1a2; herbicide; thaliana plants ... See more keywords