Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes
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DOI: 10.1038/s41598-018-23350-1
Abstract: Identification of inter-individual variability for drug metabolism through cytochrome P450 2B6 (CYP2B6) enzyme is important for understanding the differences in clinical responses to malaria and HIV. This study evaluates the distribution of CYP2B6 alleles, haplotypes… read more here.
Keywords: p450 2b6; cyp2b6; botswana; variability ... See more keywords
Polymorphisms of cytochrome P450 2B6 (CYP2B6) in cynomolgus and rhesus macaques
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DOI: 10.1111/jmp.12336
Abstract: Cytochrome P450 2B6 (CYP2B6) is an important drug‐metabolizing enzyme and is expressed in liver. Although human CYP2B6 variants account for variable enzyme properties among individuals and populations, CYP2B6 genetic variants have not been investigated in… read more here.
Keywords: p450 2b6; cyp2b6 cynomolgus; cyp2b6; 2b6 cyp2b6 ... See more keywords
Prevalence of Cytochrome P450 2B6 Single Nucleotide Polymorphism in an HIV-Positive Cohort in Jos, Nigeria: Implication for HIV Therapy
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DOI: 10.4103/njcp.njcp_348_20
Abstract: Background: Africans exhibit great diversity in cytochrome P450 2B6 isoenzyme (CYP2B6), the major enzyme in efavirenz metabolism. Aim: We examined the frequency of two functional single nucleotide polymorphisms (SNPs) of the CYP2B6 pharmacogene in HIV-infected… read more here.
Keywords: p450 2b6; hiv; cyp2b6; single nucleotide ... See more keywords