Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models
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DOI: 10.1080/00498254.2017.1393121
Abstract: Abstract 1. Simulated clearances of R-warfarin and efavirenz were recently reported for individual cynomolgus monkeys genotyped for cytochrome P450 2C19 and 2C9, respectively. To expand and verify this modeling procedure, simulations of R/S-omeprazole and R/S-warfarin… read more here.
Keywords: cytochrome p450; p450 2c19; omeprazole warfarin; using individual ... See more keywords
The effects of cytochrome P450 2C19 polymorphism on the metabolism of voriconazole in vitro
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DOI: 10.2147/idr.s179078
Abstract: Background CYP/CYP450 2C19 (CYP2C19) is a highly polymorphic enzyme and exhibits individual differences in metabolic activity. The purpose of this research was mainly to explore the catalytic activities of 30 CYP2C19 variants on the substrate… read more here.
Keywords: p450 2c19; metabolism; cyp2c19 variants; effects cytochrome ... See more keywords