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1
Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08404-0
Abstract: The human cytochrome P450 2D6 (CYP2D6) enzyme is part of phase-I metabolism and metabolizes at least 20% of all clinically relevant drugs. Therefore, it is an important target for drug-drug interaction (DDI) studies. High-throughput screening…
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Keywords:
cytochrome p450;
combinatorial approach;
p450 2d6;
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2
Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14102177
Abstract: Cytochrome P450 2D6 (CYP2D6) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for CYP2D6 phenotyping. The objective of…
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Keywords:
tramadol;
cyp2d6;
ratio;
cytochrome p450 ... See more keywords