A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08404-0
Abstract: The human cytochrome P450 2D6 (CYP2D6) enzyme is part of phase-I metabolism and metabolizes at least 20% of all clinically relevant drugs. Therefore, it is an important target for drug-drug interaction (DDI) studies. High-throughput screening… read more here.
Keywords: cytochrome p450; combinatorial approach; p450 2d6;
An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study
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DOI: 10.3390/pharmaceutics14102177
Abstract: Cytochrome P450 2D6 (CYP2D6) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for CYP2D6 phenotyping. The objective of… read more here.
Keywords: tramadol; cyp2d6; ratio; cytochrome p450 ... See more keywords