A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature
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DOI: 10.1038/s41598-017-08404-0
Abstract: The human cytochrome P450 2D6 (CYP2D6) enzyme is part of phase-I metabolism and metabolizes at least 20% of all clinically relevant drugs. Therefore, it is an important target for drug-drug interaction (DDI) studies. High-throughput screening… read more here.
Keywords: cytochrome p450; combinatorial approach; p450 2d6;
An Investigation of O-Demethyl Tramadol/Tramadol Ratio for Cytochrome P450 2D6 Phenotyping: The CYTRAM Study
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DOI: 10.3390/pharmaceutics14102177
Abstract: Cytochrome P450 2D6 (CYP2D6) gene polymorphisms influence the exposure to tramadol (T) and its pharmacologically active metabolite, O-demethyl tramadol (O-dT). Tramadol has been considered as a candidate probe drug for CYP2D6 phenotyping. The objective of… read more here.
Keywords: tramadol; cyp2d6; ratio; cytochrome p450 ... See more keywords
Distribution of Cytochrome P450 2D6 (*4, *9, *10, *41) alleles in healthy population from north-west of Iran
Sign Up to like & getrecommendations! Published in 2025 at "ARYA Atherosclerosis"
DOI: 10.48305/arya.2025.42811.2980
Abstract: BACKGROUND: The CYP2D6 gene locus is complex and highly polymorphic. Given the clinical importance of the CYP2D6 enzyme in liver xenobiotic metabolism, genotyping its significant alleles among different ethnic groups is essential for evaluating the… read more here.
Keywords: cyp2d6; alleles healthy; population; p450 2d6 ... See more keywords