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Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b12136
Abstract: Cytochrome P450 2J2 (CYP2J2), a key enzyme responsible for oxidative metabolism of various xenobiotics and endogenous compounds, participates in a diverse array of physiological and pathological processes in humans. Its biological role in tumorigenesis and…
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Keywords:
fluorescent probe;
molecular design;
p450 2j2;
near infrared ... See more keywords
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Published in 2022 at "Xenobiotica"
DOI: 10.1080/00498254.2022.2137068
Abstract: Abstract 1. Cytochrome P450 2J2 (CYP2J2) shows high expression in extrahepatic tissues, including the heart and kidney and in tumours. Inhibition of CYP2J2 has attracted attention for cancer treatment because it metabolises arachidonic acid (AA)…
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Keywords:
p450 2j2;
cytochrome p450;
apatinib motesanib;
activity ... See more keywords
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Published in 2021 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2021.1896500
Abstract: Abstract Human Cytochrome P450 2J2 (CYP2J2) as an important metabolic enzyme, plays a crucial role in metabolism of polyunsaturated fatty acids (PUFAs). Elevated levels of CYP2J2 have been associated with various types of cancer, and…
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Keywords:
2j2 cyp2j2;
inhibitor;
p450 2j2;
cyp2j2 ... See more keywords