Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1.
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DOI: 10.1021/acs.jmedchem.0c00101
Abstract: Mammary tissue-restricted cytochrome P450 4Z1 (CYP4Z1) has garnered interest for its potential role in breast cancer progression. CYP4Z1-dependent metabolism of arachidonic acid preferentially generates 14,15-epoxyeicosatrienoic acid (14,15-EET), a metabolite known to influence cellular proliferation, migration,… read more here.
Keywords: cyp4z1; p450 4z1; cytochrome p450; mechanism based ... See more keywords