Structure-Based Design and Synthesis of New Estrane-Pyridine Derivatives as Cytochrome P450 (CYP) 1B1 Inhibitors.
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DOI: 10.1021/acsmedchemlett.7b00265
Abstract: Inhibition of cytochrome P450 (CYP) 1B1 is a promising therapeutic strategy, as such an inhibitor could modulate the bioactivation of procarcinogens while reducing drug resistance. Based on docking studies, the synthesis of 12 estra-1,3,5(10)-triene derivatives… read more here.
Keywords: cytochrome p450; p450 cyp; inhibitor; cyp 1b1 ... See more keywords
Effects of Fenofibrate on the Expression of Small Heterodimer Partner (SHP) and Cytochrome P450 (CYP) 2D6.
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DOI: 10.2174/1872312811666170407164631
Abstract: BACKGROUND Cytochrome P450 (CYP) 2D6 is a major drug-metabolizing enzyme, responsible for eliminating 25% of marketed drugs. We recently identified SHP as a negative regulator of CYP2D6 expression and showed that factors that alter SHP… read more here.
Keywords: p450 cyp; expression; cyp 2d6; cytochrome p450 ... See more keywords