Structural comparison of the cytochrome P450 enzymes CYP106A1 and CYP106A2 provides insight into their differences in steroid conversion
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14502
Abstract: Understanding the structural basis of the selectivity of steroid hydroxylation requires detailed structural and functional investigations on various steroid hydroxylases with different selectivities, such as the bacterial cytochrome P450 enzymes. Here, the crystal structure of… read more here.
Keywords: p450; cytochrome p450; p450 enzymes; structural comparison ... See more keywords
Modifications of diketopiperazines assembled by cyclodipeptide synthases with cytochrome P450 enzymes
Sign Up to like & getrecommendations! Published in 2021 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-021-11178-1
Abstract: Graphical abstract 2,5-Diketopiperazines are the smallest cyclic peptides comprising two amino acids connected via two peptide bonds. They can be biosynthesized in nature by two different enzyme families, either by nonribosomal peptide synthetases or by… read more here.
Keywords: carbon; modifications diketopiperazines; cyclodipeptide synthases; cytochrome p450 ... See more keywords
Functional interactions of adrenodoxin with several human mitochondrial cytochrome P450 enzymes.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108596
Abstract: Seven of the 57 human cytochrome P450 (P450) enzymes are mitochondrial and carry out important reactions with steroids and vitamins A and D. These seven P450s utilize an electron transport chain that includes NADPH, NADPH-adrenodoxin… read more here.
Keywords: functional interactions; p450; cytochrome p450; adx ... See more keywords
Atypical Michaelis-Menten kinetics in cytochrome P450 enzymes: A focus on substrate inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.08.017
Abstract: Abstract The widespread applications of the century-old Michaelis-Menten kinetics in the characterization of drug-metabolizing cytochrome P450 enzymes have persisted since their discovery in the 1950s. This is a concern given preceding reports of atypical Michaelis-Menten… read more here.
Keywords: michaelis menten; menten kinetics; cytochrome p450; p450 enzymes ... See more keywords
Molecular probes for human cytochrome P450 enzymes: Recent progress and future perspectives
Sign Up to like & getrecommendations! Published in 2021 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2020.213600
Abstract: Abstract The cytochrome P450 enzymes (P450s or CYPs) are a class of heme-containing monooxygenases responsible for the oxidative metabolism of a wide range of endogenous substances and foreign chemicals. Deciphering the physiological functions of CYPs… read more here.
Keywords: cytochrome p450; probes human; p450 enzymes; probe substrates ... See more keywords
Targeted mutagenesis of CYP76AK2 and CYP76AK3 in Salvia miltiorrhiza reveals their roles in tanshinones biosynthetic pathway.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.08.112
Abstract: Salvia miltiorrhiza Bunge, belonging to Lamiaceae family, is one of the most important Chinese medicinal herbs. The dried roots, also called Danshen in Chinese, are usually used in the formula of Chinese traditional medicine due… read more here.
Keywords: tanshinones biosynthetic; miltiorrhiza; cyp76ak3; cyp76ak2 cyp76ak3 ... See more keywords
Intersection of the Roles of Cytochrome P450 Enzymes with Xenobiotic and Endogenous Substrates: Relevance to Toxicity and Drug Interactions.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.6b00226
Abstract: Today much is known about cytochrome P450 (P450) enzymes and their catalytic specificity, but the range of reactions catalyzed by each still continues to surprise. Historically, P450s had been considered to be involved in either… read more here.
Keywords: drug; p450; cytochrome p450; intersection roles ... See more keywords
Theoretical Insights into the Mechanism and Stereoselectivity of Olefin Cyclopropanation Catalyzed by Two Engineered Cytochrome P450 Enzymes.
Sign Up to like & getrecommendations! Published in 2018 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.8b01875
Abstract: Engineered P450s can catalyze some non-natural reactions with high efficiency and excellent selectivity, such as the carbine transfer, nitrene transfer, C-H insertion, and C-H amination, opening alternative routes for sustainable production of chemicals. Recent experiments… read more here.
Keywords: cyclopropanation; two engineered; engineered cytochrome; cytochrome p450 ... See more keywords
Efficient O-demethylation of lignin monoaromatics using the peroxygenase activity of cytochrome P450 enzymes.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc04698a
Abstract: A crucial reaction in harnessing renewable carbon from lignin is O-demethylation. We demonstrate the selective O-demethylation of syringol and guaiacol using different cytochrome P450 enzymes. These can efficiently use hydrogen peroxide which, when compared to… read more here.
Keywords: lignin; p450 enzymes; demethylation; demethylation lignin ... See more keywords
Efficient heterologous expression of cytochrome P450 enzymes in microorganisms for the biosynthesis of natural products
Sign Up to like & getrecommendations! Published in 2022 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2022.2029344
Abstract: Abstract Natural products, a chemically and structurally diverse class of molecules, possess a wide spectrum of biological activities, have been used therapeutically for millennia, and have provided many lead compounds for the development of synthetic… read more here.
Keywords: p450 enzymes; natural products; biosynthesis natural; cytochrome p450 ... See more keywords
In vitro study on the effect of peucedanol on the activity of cytochrome P450 enzymes
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2021.1944223
Abstract: Abstract Context Peucedanol is a major extract of Peucedanum japonicum Thunb. (Apiaceae) roots, which is a commonly used herb in paediatrics. Its interaction with cytochrome P450 enzymes (CYP450s) would lead to adverse effects or even… read more here.
Keywords: effect peucedanol; study; peucedanol; cytochrome p450 ... See more keywords