Cytochrome P450-mediated herbicide metabolism in plants: Current understanding and prospects.
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.6040
Abstract: Cytochrome P450s (P450s) have been the center of herbicide metabolism research due to their ability to endow selectivity in crops and resistance in weeds. In the last 20 years, around 30 P450s from diverse plant species… read more here.
Keywords: p450 mediated; mediated herbicide; herbicide; herbicide metabolism ... See more keywords
An improved quantum mechanical model of P450-mediated aromatic oxidation
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Pharmacokinetics"
DOI: 10.1016/j.dmpk.2017.11.213
Abstract: The Cytochrome P450 enzymes (P450s) are a large family of monooxygenases involved in the metabolism of drugs via oxidative reactions such as C-H bond hydroxylation, epoxidation and heteroatom oxidation. It has become increasingly important, within… read more here.
Keywords: p450 mediated; aromatic oxidation; metabolism; model ... See more keywords
Assessing Alkene Reactivity toward Cytochrome P450-Mediated Epoxidation through Localized Descriptors and Regression Modeling
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01567
Abstract: The prediction of sites of epoxidation by cytochrome P450s during metabolism is particularly important in drug design, as epoxides are capable of alkylating biological macromolecules. Reliable methods are needed to quantitatively predict P450-mediated epoxidation barriers… read more here.
Keywords: epoxidation; p450 mediated; mediated epoxidation; reactivity ... See more keywords