Highly selective bile acid hydroxylation by the multifunctional bacterial P450 monooxygenase CYP107D1 (OleP)
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Letters"
DOI: 10.1007/s10529-020-02813-4
Abstract: Objective Regio- and stereoselective hydroxylation of lithocholic acid (LCA) using CYP107D1 (OleP), a cytochrome P450 monooxygenase from the oleandomycin synthesis pathway of Streptomyces antibioticus . Results Co-expression of CYP107D1 from S. antibioticus and the reductase/ferredoxin… read more here.
Keywords: cyp107d1 olep; hydroxylation; monooxygenase cyp107d1; p450 monooxygenase ... See more keywords
Enhancing NADPH regeneration and increasing hydroxylation efficiency with P450 monooxygenase through strengthening expression of glucose-6-phosphate dehydrogenase in industrial filamentous fungi
Sign Up to like & getrecommendations! Published in 2017 at "Biocatalysis and agricultural biotechnology"
DOI: 10.1016/j.bcab.2017.08.004
Abstract: Abstract Cytochrome P450 monooxygenases are a unique family of enzymes that are able to catalyze regio- and stereospecific oxidations for a broad substrate range. However, their highly-effective industrial application is often limited by the regeneration… read more here.
Keywords: hydroxylation; nadph regeneration; enhancing nadph; regeneration ... See more keywords
Multifunctional P450 Monooxygenase CftA Diversifies the Clifednamide Pool through Tandem C-H Bond Activations.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.1c00606
Abstract: Polycyclic tetramate macrolactams (PTMs) are a class of structurally complex hybrid polyketide-nonribosomal peptide (PK-NRP) natural products produced by diverse bacteria. Several PTMs display pharmaceutically interesting bioactivities, and the early stages of PTM biosynthesis involving polyketide… read more here.
Keywords: multifunctional p450; p450 monooxygenase; cfta; clifednamide ... See more keywords
3,6-Dichlorosalicylate Catabolism Is Initiated by the DsmABC Cytochrome P450 Monooxygenase System in Rhizorhabdus dicambivorans Ndbn-20
Sign Up to like & getrecommendations! Published in 2017 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02133-17
Abstract: ABSTRACT The degradation of the herbicide dicamba is initiated by demethylation to form 3,6-dichlorosalicylate (3,6-DCSA) in Rhizorhabdus dicambivorans Ndbn-20. In the present study, a 3,6-DCSA degradation-deficient mutant, Ndbn-20m, was screened. A cluster, dsmR1DABCEFGR2, was lost… read more here.
Keywords: cytochrome p450; catabolism; dicambivorans ndbn; p450 monooxygenase ... See more keywords