Electrochemically boosted cytochrome P450 reaction that efficiently produces 25-hydroxyvitamin D3
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Catalysis"
DOI: 10.1016/j.jcat.2020.02.012
Abstract: Abstract We investigated electrochemical P450 vitamin D3 hydroxylase (Vdh) reactions using promiscuous spinach ferredoxin and a small organic molecule as the mediators that shuttle electrons from the electrode to the P450. The choice of small… read more here.
Keywords: electrochemically boosted; hydroxyvitamin; p450 reaction; boosted cytochrome ... See more keywords
An Improved Method for Cytochrome P450 Reaction Phenotyping Using a Sequential Qualitative-Then-Quantitative Approach
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.000883
Abstract: Cytochrome P450 reaction phenotyping to determine the fraction of metabolism (fm) values for individual enzymes is a standard study in the evaluation of a new drug. However, there are technical challenges in these studies caused… read more here.
Keywords: step; reaction phenotyping; p450 reaction; drug ... See more keywords