A dynamic understanding of cytochrome P450 structure and function through solution NMR.
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DOI: 10.1016/j.copbio.2020.11.007
Abstract: Many economically important biosyntheses incorporate regiospecific and stereospecific oxidations at unactivated carbons. Such oxidations are commonly catalyzed by cytochrome P450 monooxygenases, heme-containing enzymes that activate molecular oxygen while selectively binding and orienting the substrate for… read more here.
Keywords: understanding cytochrome; dynamic understanding; solution; p450 ... See more keywords
Cytochrome P450 Structure, Function and Clinical Significance: A Review.
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DOI: 10.2174/1389450118666170125144557
Abstract: BACKGROUND The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. Induction or inhibition of CYP enzymes is a major mechanism that underlies… read more here.
Keywords: drug; cyp enzymes; p450 structure; cytochrome p450 ... See more keywords