Putidaredoxin Binds to the Same Site on Cytochrome P450cam in the Open and Closed Conformation.
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DOI: 10.1021/acs.biochem.7b00564
Abstract: Cytochrome P450 CYP101A1 (P450cam) hydroxylates camphor by receiving two distinct electrons from its unique reductase, putidaredoxin (Pdx). Upon binding ferric P450cam, Pdx is now known to trigger a conformational change in the enzyme. This Pdx-induced… read more here.
Keywords: open closed; p450cam; conformation; site ... See more keywords
Conformational Change Induced by Putidaredoxin Binding to Ferrous CO-ligated Cytochrome P450cam Characterized by 2D IR Spectroscopy
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DOI: 10.3389/fmolb.2018.00094
Abstract: The importance of conformational dynamics to protein function is now well-appreciated. An outstanding question is whether they are involved in the effector role played by putidaredoxin (Pdx) in its reduction of the O2 complex of… read more here.
Keywords: ferrous ligated; p450cam; conformational change; pdx ... See more keywords