Cross-resistance profiles of malaria mosquito P450s associated with pyrethroid resistance against WHO insecticides.
Sign Up to like & getrecommendations! Published in 2019 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2019.06.007
Abstract: Extensive use of pyrethroids for malaria control in Africa has led to widespread pyrethroid resistance in the two major African vectors of malaria An. gambiae and An. funestus. This is often associated with constitutively elevated… read more here.
Keywords: associated pyrethroid; control; cross resistance; resistance ... See more keywords
Exploring the molecular basis for selective C–H functionalization in plant P450s
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2020.05.001
Abstract: Highly prevalent in nature, cytochrome P450 enzymes are powerful biocatalysts for selective C–H functionalization [1]. These heme-containing enzymes activate inert C–H bonds within complex molecules for a plethora of transformations with exquisite regio-, chemoand stereoselectivity.… read more here.
Keywords: plant; selective functionalization; molecular basis; p450s ... See more keywords
Transcription profiling and characterization of Dermanyssus gallinae cytochrome P450 genes involved in beta-cypermethrin resistance.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary parasitology"
DOI: 10.1016/j.vetpar.2020.109155
Abstract: The poultry red mite, Dermanyssus gallinae, poses a significant threat to hen health and poultry husbandry. D. gallinae has typically been controlled using synthetic acaricides, like pyrethroids, but increased resistance to pyrethroids has been found… read more here.
Keywords: four p450s; p450s genes; beta cypermethrin; expression ... See more keywords
Metabolites of Cannabigerol Generated by Human Cytochrome P450s Are Bioactive.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00383
Abstract: The phytocannabinoid cannabigerol (CBG) is the central biosynthetic precursor to many cannabinoids, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Though the use of CBG has recently witnessed a widespread surge because of its beneficial health effects… read more here.
Keywords: human cytochrome; cbg; mass spectrometry; cytochrome p450s ... See more keywords
Set of Cytochrome P450s Cooperatively Catalyzes the Synthesis of a Highly Oxidized and Rearranged Diterpene-Class Sordarinane Architecture.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12427
Abstract: Cytochrome P450s are one of the most versatile oxidases that catalyze significant and unique chemical transformations for the construction of complex structural frameworks during natural product biosynthesis. Here, we discovered a set of P450s, including… read more here.
Keywords: sordarinane architecture; p450s; cytochrome p450s; highly oxidized ... See more keywords
Impact of lifestyle on cytochrome P450 monooxygenase repertoire is clearly evident in the bacterial phylum Firmicutes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-70686-8
Abstract: Cytochrome P450 monooxygenases (CYPs/P450s), heme thiolate proteins, are well known for their role in organisms’ primary and secondary metabolism. Research on eukaryotes such as animals, plants, oomycetes and fungi has shown that P450s profiles in… read more here.
Keywords: species belonging; phylum firmicutes; impact lifestyle; p450 ... See more keywords
Perspective of the Induction of Liver Microsomal Cytochrome P450s by Chemical Compounds
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.000891
Abstract: The concept of hepatic induction of drug-metabolizing cytochrome P450s (P450s) by xenobiotics, including therapeutic drugs, was proposed in the early 1960s. A polycyclic aromatic hydrocarbon and phenobarbital have been the two major inducers used to… read more here.
Keywords: cytochrome p450s; induction liver; p450s; perspective induction ... See more keywords
Saprophytic to Pathogenic Mycobacteria: Loss of Cytochrome P450s Vis a Vis Their Prominent Involvement in Natural Metabolite Biosynthesis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010149
Abstract: Cytochrome P450 monooxygenases (P450s/CYPs) are ubiquitous enzymes with unique regio- and stereo-selective oxidation activities. Due to these properties, P450s play a key role in the biosynthesis of natural metabolites. Mycobacterial species are well-known producers of… read more here.
Keywords: biosynthesis; natural metabolite; vis vis; p450s ... See more keywords