Single-Molecule Force Spectroscopy Reveals the Mechanical Role of p47 in Protein Stabilization.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.4c00878
Abstract: Mechanical force plays a pivotal role in regulating protein folding, trafficking, and processing in cells. While canonical chaperones are well-known to govern force-responsive conformational transitions, the capacity of accessory cofactors to directly modulate substrate mechanics… read more here.
Keywords: spectroscopy; p47; force; mechanical role ... See more keywords
Targeting NOX2 via p47/phox-p22/phox Inhibition with Novel Triproline Mimetics.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00094
Abstract: On the basis of the knowledge that the proline-rich hot spot PPPRPP region of P(151)PSNPPPRPP(160), an oligopeptide derived from the cytosolic portion of p22phox (p22), binds to the single functional bis-SH3 domain of the regulatory… read more here.
Keywords: phox; triproline; p47; targeting nox2 ... See more keywords
Translocator protein (18 kDa) regulates the microglial phenotype in Parkinson’s disease through P47
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DOI: 10.1080/21655979.2022.2068754
Abstract: ABSTRACT Numerous studies have suggested that the phenotypic transformation of microglia plays a role in the pathogenesis of Parkinson’s disease (PD). Translocator protein (TSPO) is an 18 kDa translocator membrane protein that acts as a… read more here.
Keywords: p47; translocator protein; parkinson disease; tspo ... See more keywords