Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.09.011
Abstract: Abstract Although critical in phagocytosis in innate immunity, reactive oxygen species (ROS) collaterally inflict damage to host phagocytes because they indiscriminate targets. Since Nrf2 increases the expression of anti‐oxidant enzymes that nullifies ROS, ROS activating… read more here.
Keywords: ubiquitination nrf2; p47phox; nrf2 p47phox; expression ... See more keywords
p47phox deficiency impairs platelet function and protects mice against arterial and venous thrombosis
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101569
Abstract: NADPH oxidase-derived reactive oxygen species (ROS) regulates platelet function and thrombosis. It remains controversial regarding NOX2’s role in platelet function. As a regulatory subunit for NOX2, whether p47phox regulates platelet function remains unclear. Our study… read more here.
Keywords: platelet function; p47phox; arterial venous; p47phox deficiency ... See more keywords
Eugenol prevents fMLF-induced superoxide anion production in human neutrophils by inhibiting ERK1/2 signaling pathway and p47phox phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55043-8
Abstract: Eugenol is a polyphenol extracted from Syzygium aromaticum essential oil. It is known to have anti-inflammatory and chemoprotective properties as well as a potent anti-oxidant activity due the presence of its phenolic group. In this… read more here.
Keywords: p47phox; production; human neutrophils; superoxide anion ... See more keywords
NCF1 (p47phox)-deficient chronic granulomatous disease: comprehensive genetic and flow cytometric analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2018023184
Abstract: Mutations in NCF1 (p47phox) cause autosomal recessive chronic granulomatous disease (CGD) with abnormal dihydrorhodamine (DHR) assay and absent p47phox protein. Genetic identification of NCF1 mutations is complicated by adjacent highly conserved (>98%) pseudogenes (NCF1B and… read more here.
Keywords: ncf1 p47phox; p47phox; granulomatous disease; chronic granulomatous ... See more keywords