Arglabin regulates microglia polarization to relieve neuroinflammation in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23045
Abstract: Arglabin (Arg) is a derivative of parthenolide. At present, there are few reports on the pharmacological effects and targets of Arg. In this study, we aimed to explore the relationship between Arg and NF-κB (P50)… read more here.
Keywords: expression; p50 p50; polarization; bv2 cells ... See more keywords
SOCS1 S-Nitrosation in the nucleus is a switch of macrophage polarization and function
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.239
Abstract: Macrophages play a critical role in inflammation initiation, progression and resolution due to their capacity to assume both pro- and anti-inflammatory phenotypes. The molecular mechanisms that regulate these transitions are of great clinical interest but… read more here.
Keywords: p50; nitrosation nucleus; macrophage polarization; inflammatory ... See more keywords
Hippocampal and anterior cingulate cortex contribution to the processing of recently-acquired and remotely stored spatial memories in rats trained during preadolescence
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2020.107271
Abstract: Preadolescent development is characterized by a reorganization of connectivity within and between brain regions that coincides with the emergence of more complex behaviors. The hippocampus is one such region that undergoes extensive preadolescent remodeling and… read more here.
Keywords: p50; spatial memories; group; cingulate cortex ... See more keywords
p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18838-2
Abstract: p50, the mature product of NFKB1, is constitutively produced from its precursor, p105. Here, we identify BARD1 as a p50-interacting factor. p50 directly associates with the BARD1 BRCT domains via a C-terminal phospho-serine motif. This… read more here.
Keywords: mono ubiquitination; p50; bard1; cell cycle ... See more keywords
The dependence of maximum oxygen uptake on hemoglobin-oxygen affinity and altitude: a computational modeling approach
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5716173
Abstract: Background: Hemoglobin, the primary oxygen-carrying protein in humans, provides the intermediate link between pulmonary oxygen uptake and tissue oxygen consumption. Oxygen transport is greatly influenced by the hemoglobin-oxygen affinity, which is commonly characterized by the… read more here.
Keywords: p50; low p50; physiology; oxygen ... See more keywords
Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-019-1446-z
Abstract: BackgroundWhile NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory priming is poorly understood.MethodsMale NF-κB… read more here.
Keywords: function; p50; p50 mice; month old ... See more keywords
Elevated metabolic rate and skeletal muscle oxidative metabolism contribute to the reduced susceptibility of NF‐κB p50 null mice to obesity
Sign Up to like & getrecommendations! Published in 2018 at "Physiological Reports"
DOI: 10.14814/phy2.13836
Abstract: Mice with a deletion of the p50 subunit of the proinflammatory nuclear factor kappa B pathway (NF‐κB p50) have reduced weight compared to wild‐type control mice. However, the physiological underpinning of this phenotype remains unknown.… read more here.
Keywords: oxidative metabolism; skeletal muscle; p50; mice ... See more keywords
PLCE1 Promotes the Invasion and Migration of Esophageal Cancer Cells by Up-Regulating the PKCα/NF-κB Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Yonsei Medical Journal"
DOI: 10.3349/ymj.2018.59.10.1159
Abstract: Purpose To investigate the effect and mechanism of phospholipase C epsilon gene 1 (PLCE1) expression on esophageal cancer cell lines. Materials and Methods The esophageal carcinoma cell lines Eca109 and EC9706 and normal esophageal epithelial… read more here.
Keywords: esophageal cancer; p50; plce1; expression ... See more keywords
A Pathogenic Missense Variant in NFKB1 Causes Common Variable Immunodeficiency Due to Detrimental Protein Damage
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.621503
Abstract: In common variable immunodeficiency (CVID), heterozygous damaging NFKB1 variants represent the most frequent monogenic cause. NFKB1 encodes the precursor p105, which undergoes proteasomal processing to generate the mature NF-κB transcription factor subunit p50. The majority… read more here.
Keywords: protein; p50; tyr350cys; missense variant ... See more keywords
Importance of Sequencing HBA1, HBA2 and HBB Genes to Confirm the Diagnosis of High Oxygen Affinity Hemoglobin
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13010132
Abstract: High oxygen affinity hemoglobin (HOAH) is the main cause of constitutional erythrocytosis. Mutations in the genes coding the alpha and beta globin chains (HBA1, HBA2 and HBB) strengthen the binding of oxygen to hemoglobin (Hb),… read more here.
Keywords: hba2 hbb; hbb; p50; hba1 hba2 ... See more keywords