Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515.
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DOI: 10.1021/acsmedchemlett.8b00569
Abstract: Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in signaling and repair of DNA single strand breaks. PARP-1 employs NAD+ to modify substrate proteins via the attachment of poly(ADP-ribose) chains. PARP-1 is a well established target… read more here.
Keywords: p515; inhibitor; nms p515; discovery stereospecific ... See more keywords