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Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13641
Abstract: The voltage‐gated sodium channels (VGSCs) are aberrantly expressed in a variety of tumors and play an important role in tumor growth and metastasis. Here, we show that VGSCs auxiliary β3 subunit, encoded by the SCN3B…
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Keywords:
degradation;
p53 degradation;
p53;
gated sodium ... See more keywords
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Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14461
Abstract: The tumour suppressor p53 has been implicated in the host defence system against hepatitis C virus (HCV) infection, although the detailed mechanism remains unknown. Here, we found that p53 inhibits HCV replication by downregulating HCV…
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Keywords:
core;
suppressor p53;
p53;
hcv core ... See more keywords
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Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12477
Abstract: Polo‐like kinase 1 (Plk1), a master regulator of mitosis and the DNA damage response, is considered to be an intriguing target in the research field of mitotic intervention. The observation that Plk1 is overexpressed in…
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Keywords:
plk1;
like kinase;
volasertib;
polo like ... See more keywords
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Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12593
Abstract: Hepatocellular carcinoma (HCC), with its ineffective therapeutic options and poor prognosis, represents a global threat. In the present study, we show that RAD52 motif 1 (RDM1), a key regulator of DNA double‐strand break repair and…
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Keywords:
hepatocellular carcinoma;
loss rdm1;
rdm1;
p53 ... See more keywords
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Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13118
Abstract: Breast cancer is the most diagnosed malignancy in women, with over half a million women dying from this disease each year. In our previous studies, ∆40p53, an N-terminally truncated p53 isoform, was found to be…
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Keywords:
breast;
breast cancer;
cancer;
p53 ... See more keywords
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Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13421
Abstract: LIM protein-domain containing protein Ajuba (encoded by AJUBA) functions as a scaffold protein to regulate protein-protein interactions, signaling transduction and genes transcription. AJUBA expression is higher in colorectal cancer (CRC) tissues compared with normal tissues,…
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Keywords:
protein ajuba;
p53;
protein;
domain containing ... See more keywords
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Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12985
Abstract: Malignant mesothelioma (MM) is an aggressive malignant neoplasm which rapidly invades pleural tissues and has a poor prognosis. Here, we explore enhancement of the effect of irinotecan [camptothecin‐11 (CPT‐11)] by the p53‐dependent induction of carboxylesterase…
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Keywords:
use irinotecan;
cpt;
mesothelioma;
p53 ... See more keywords
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Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204599
Abstract: P53 inactivation occurs in about 50% of human cancers, where p53‐driven p21 activity is devoid and p27 becomes essential for the establishment of the G1/S checkpoint upon DNA damage. Here, this work shows that the…
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Keywords:
p27;
lncrna limp27;
p53 defective;
dna damage ... See more keywords
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Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24778
Abstract: The tumor suppressors B‐lymphocyte‐induced maturation protein‐1 (BLIMP‐1) and p53 play a crucial role in B‐cell lymphomas, and their inactivation contributes to the pathogenesis of a wide spectrum of lymphoid malignancies, including diffuse large B‐cell lymphomas…
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Keywords:
loss blimp;
blimp;
blimp p53;
model ... See more keywords
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Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21970
Abstract: Microplitis bicoloratus parasitism can induce apoptosis of hemocytes in the M. bicolortus host, Spodoptera litura. However, it is unclear how M. bicolortus parasitism regulates host signaling pathways to induce apoptosis. Expression of cyclophilin D (CypD)…
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Keywords:
parasitism;
litura;
cypd;
induce apoptosis ... See more keywords
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Published in 2017 at "Birth defects research"
DOI: 10.1002/bdr2.1094
Abstract: BACKGROUND Neural tube defects (NTDs) are among the most common and severe congenital malformations of the central nervous system. Animal studies have shown that apoptosis is involved in the development of NTDs. However, little evidence…
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Keywords:
apoptosis;
pax3;
central nervous;
expression ... See more keywords