Context-Dependent Function of Long Noncoding RNA PURPL in Transcriptome Regulation during p53 Activation
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DOI: 10.1128/mcb.00289-22
Abstract: PURPL is a p53-induced lncRNA that suppresses basal p53 levels. Here, we investigated PURPL upon p53 activation in liver cancer cells, where it is expressed at significantly higher levels than other cell types. ABSTRACT PURPL… read more here.
Keywords: function; p53 activation; upon p53; purpl ... See more keywords
p53 activation during ribosome biogenesis regulates normal erythroid differentiation.
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DOI: 10.1182/blood.2019003439
Abstract: The role of ribosome biogenesis in erythroid development is supported by the recognition of erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q- syndrome. Whether ribosome biogenesis exerts a regulatory function on normal erythroid… read more here.
Keywords: p53 activation; erythroid; biogenesis; ribosome biogenesis ... See more keywords
The Δ40p53 isoform inhibits p53-dependent eRNA transcription and enables regulation by signal-specific transcription factors during p53 activation
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DOI: 10.1371/journal.pbio.3001364
Abstract: The naturally occurring Δ40p53 isoform heterotetramerizes with wild-type p53 (WTp53) to regulate development, aging, and stress responses. How Δ40p53 alters WTp53 function remains enigmatic because their co-expression causes tetramer heterogeneity. We circumvented this issue with… read more here.
Keywords: 40p53 isoform; transcription; 40p53 wtp53; p53 activation ... See more keywords
Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy
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DOI: 10.1371/journal.pone.0189051
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extremely dense fibrotic stroma, which contributes to tumor growth, metastasis, and drug resistance. During tumorigenesis, quiescent pancreatic stellate cells (PSCs) are activated and become major contributors to… read more here.
Keywords: stromal p53; pancreatic stellate; activation; p53 activation ... See more keywords
AMP-activated protein kinase contributes to ROS-mediated p53 activation in cisplatin-induced nephrotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202111_27114
Abstract: OBJECTIVE Cisplatin is a widely used anticancer drug that provokes various side effects. Nephrotoxicity is one of the well-known major side effects in the chemotherapeutic use of cisplatin. Reactive oxygen species (ROS) and p53 play… read more here.
Keywords: activation; p53 activation; nephrotoxicity; cisplatin ... See more keywords
Olaparib Induces RPL5/RPL11-Dependent p53 Activation via Nucleolar Stress
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DOI: 10.3389/fonc.2022.821366
Abstract: The poly (ADP-ribose) polymerase (PARP) inhibitor (PARPi) Olaparib is a widely used targeted therapy for a variety of solid tumors with homologous recombination deficiency (HRD) caused by mutation of BRCA1/2 or other DNA repair genes.… read more here.
Keywords: rpl5 rpl11; p53 activation; nucleolar stress; p53 ... See more keywords
Ergosterol Peroxide Inhibits Porcine Epidemic Diarrhea Virus Infection in Vero Cells by Suppressing ROS Generation and p53 Activation
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DOI: 10.3390/v14020402
Abstract: Porcine epidemic diarrhea virus (PEDV) is an alphacoronavirus that causes severe watery diarrhea in piglets with high morbidity and mortality, resulting in serious economic losses to the farming industry. Ergosterol peroxide (EP) is a sterol… read more here.
Keywords: p53 activation; pedv induced; infection; pedv infection ... See more keywords