A non-invasive iRFP713 p53 reporter reveals dynamic p53 activity in response to irradiation and liver regeneration in vivo†
Sign Up to like & getrecommendations! Published in 2022 at "Science signaling"
DOI: 10.1126/scisignal.abd9099
Abstract: Genetically encoded probes are widely used to visualize cellular processes in vitro and in vivo. Although effective in cultured cells, fluorescent protein tags and reporters are suboptimal in vivo because of poor tissue penetration and… read more here.
Keywords: reporter; p53 activity; p53; response ... See more keywords
Abstract 3536: SENP1 is a p53 deSUMOylating enzyme and its depletion induces p53 activity
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-3536
Abstract: SUMOylation plays important roles in diverse cellular processes by regulating protein-protein interaction, protein localization, trafficking, stability and activity. p53 can by SUMOyalted at lysine (K) 384. Yet, how SUMOylation regulates p53 activity remain unclear. SUMOylation… read more here.
Keywords: desumoylating enzyme; p53 activity; p53 desumoylating; depletion ... See more keywords
The altered activity of P53 signaling pathway by STK11 gene mutations and its cancer phenotype in Peutz-Jeghers syndrome
Sign Up to like & getrecommendations! Published in 2018 at "BMC Medical Genetics"
DOI: 10.1186/s12881-018-0626-5
Abstract: BackgroundPeutz-Jeghers syndrome (PJS) is caused by mutations in serine/threonine kinase 11 (STK11) gene. The increased cancer risk has been connected to P53 pathway.MethodsPJS probands with STK11 mutation were included in the function analysis. P53 activity… read more here.
Keywords: stk11 gene; p53 activity; jeghers syndrome; cancer ... See more keywords
The Impact of NRF2 Inhibition on Drug-Induced Colon Cancer Cell Death and p53 Activity: A Pilot Study
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DOI: 10.3390/biom12030461
Abstract: Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 (NRF2) protein is the master regulator of oxidative stress, which is at the basis of various chronic diseases including cancer. Hyperactivation of NRF2 in already established cancers… read more here.
Keywords: cell; inhibition; p53 activity; p53 ... See more keywords
Regulation of p53 Activity by (+)-Epiloliolide Isolated from Ulva lactuca
Sign Up to like & getrecommendations! Published in 2021 at "Marine Drugs"
DOI: 10.3390/md19080450
Abstract: Ulva lactuca (U. lactuca) is a green alga distributed worldwide and used as a food and cosmetic material. In our previous study, we determined the effects of U. lactuca methanol extracts on the UVB-induced DNA… read more here.
Keywords: demonstrated epiloliolide; ulva lactuca; epiloliolide decreased; p53 activity ... See more keywords