Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers
Sign Up to like & getrecommendations! Published in 2019 at "Protein & Cell"
DOI: 10.1007/s13238-019-0634-z
Abstract: While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high… read more here.
Keywords: apoptosis; inhibition p53; p53 akt; p53 ... See more keywords
Tannic acid-stabilized gold nano-particles are superior to native tannic acid in inducing ROS-dependent mitochondrial apoptosis in colorectal carcinoma cells via the p53/AKT axis
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra00808j
Abstract: Tannic acid and AuNP-TA lead to death of colon cancer cells via the ROS/p53/Akt pathway, and AuNP-TA is more potent. read more here.
Keywords: cells via; tannic acid; acid stabilized; stabilized gold ... See more keywords