Direct evidence of cellular transformation by prion-like p53 amyloid infection.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell science"
DOI: 10.1242/jcs.258316
Abstract: Tumor suppressor p53 mutations are associated with more than 50% of cancers. Aggregation and amyloid formation of p53 is also implicated in cancer pathogenesis, but direct evidence for aggregated p53 amyloids acting as an oncogene… read more here.
Keywords: p53; p53 amyloid; cellular transformation; direct evidence ... See more keywords
Oncogenic gain of function due to p53 amyloids by aberrant alteration of cell cycle and proliferation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259500
Abstract: Transcription factor p53 has been shown to aggregate into cytoplasmic/nuclear inclusions, compromising its native tumor suppressive functions. Recently, p53 is shown to form amyloids, which play a role in conferring cancerous properties to cells leading… read more here.
Keywords: oncogenic gain; cell; p53 amyloid; cell cycle ... See more keywords
PRIMA-1 inhibits Y220C p53 amyloid aggregation and synergizes with cisplatin in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1165132
Abstract: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Although many therapeutic options are available, several factors, including the presence of p53 mutations, impact tumor development and therapeutic resistance. TP53 is the… read more here.
Keywords: aggregation; hepatocellular carcinoma; p53 amyloid; mutant p53 ... See more keywords