Abstract 4190: A promising blood-brain-barrier penetrant MDM2-p53 antagonist, BI-MDM2, increases survival in orthotopic, glioblastoma patient-derived xenograft models
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DOI: 10.1158/1538-7445.am2020-4190
Abstract: Robust function of the p53 tumor suppressor pathway is critical when treating with DNA-damage inducing agents such as radiation therapy (RT), which is a key component of standard care for GBM. MDM2 is an important… read more here.
Keywords: antagonist mdm2; mdm2; penetrant mdm2; p53 antagonist ... See more keywords