Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library
Sign Up to like & getrecommendations! Published in 2017 at "Science Advances"
DOI: 10.1126/sciadv.1701383
Abstract: The unspliced form of XBP1 stabilizes MDM2 protein by inhibiting its ubiquitination and regulates the MDM2/p53 axis. Cell cycle progression is a tightly controlled fundamental process in living cells, with any defects being closely linked… read more here.
Keywords: p53 axis; p53; regulator; mdm2 p53 ... See more keywords
The Sirt1/P53 Axis in Diabetic Intervertebral Disc Degeneration Pathogenesis and Therapeutics
Sign Up to like & getrecommendations! Published in 2019 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2019/7959573
Abstract: Intervertebral disc degeneration (IDD) is one of the major causes of low back pain. Diabetes is a risk factor for IDD and may aggravate IDD in rats; however, the mechanism is poorly understood. Previously, we… read more here.
Keywords: apoptosis senescence; p53 axis; intervertebral disc; p53 ... See more keywords